PYGB Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N6-Methyladenosine 5′-monophosphate sodium salt | 81921-35-9 | sc-215524A sc-215524B sc-215524 sc-215524D sc-215524C | 5 mg 10 mg 25 mg 100 mg 50 mg | $169.00 $254.00 $417.00 $999.00 $699.00 | 8 | |
N6-Methyladenosine 5'-monophosphate sodium salt serves as a crucial regulator in cellular signaling pathways, particularly in RNA metabolism. Its unique ability to interact with specific RNA-binding proteins facilitates the recognition and modification of mRNA, influencing stability and translation efficiency. The compound exhibits distinct kinetic properties, allowing for rapid incorporation into RNA structures, which can modulate gene expression dynamics. Its ionic nature enhances solubility, promoting effective cellular interactions. | ||||||
Adenosine 5′-Monophosphate, Disodium Salt | 4578-31-8 | sc-202444 sc-202444A sc-202444B sc-202444C | 5 g 25 g 100 g 1 kg | $60.00 $161.00 $265.00 $926.00 | ||
AMP is a natural activator of PYGB, binding to the enzyme allosterically to induce a conformational change that activates PYGB. This activation promotes the breakdown of glycogen into glucose-1-phosphate. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Increased intracellular calcium levels activate PYGB in muscle cells. Calcium binds to calmodulin, which activates phosphorylase kinase. Phosphorylase kinase then phosphorylates and activates PYGB, leading to glycogen breakdown for energy production. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP activates protein kinase A (PKA), initiating a crucial role in glycogen metabolism. PKA phosphorylates phosphorylase kinase, which activates PYGB. This cascade of events ultimately leads to glycogen breakdown. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to β-adrenergic receptors on muscle cells, initiating a cAMP-dependent signaling pathway. This pathway activates PKA, leading to phosphorylase kinase activation and, subsequently, PYGB activation, promoting glycogenolysis. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol mimics the effects of epinephrine by binding to β-adrenergic receptors and initiating a cAMP-dependent signaling cascade that activates PYGB, leading to glycogenolysis in muscle cells. | ||||||
Diazoxide | 364-98-7 | sc-200980 | 1 g | $300.00 | 5 | |
Diazoxide increases the release of catecholamines, such as epinephrine, which then activate PYGB indirectly via cAMP-dependent pathways, resulting in glycogen breakdown. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin increases intracellular calcium levels, activating phosphorylase kinase. Activated phosphorylase kinase then activates PYGB, initiating glycogenolysis in muscle cells. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can activate PYGB indirectly by promoting the release of catecholamines, similar to diazoxide. These catecholamines subsequently activate PYGB via cAMP-dependent signaling pathways. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine, a β-adrenergic receptor agonist, activates PYGB through cAMP-dependent pathways, mimicking the effects of epinephrine and promoting glycogen breakdown. | ||||||