Date published: 2025-10-16

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N6-Methyladenosine 5′-monophosphate sodium salt (CAS 81921-35-9)

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Alternate Names:
N6-Methyladenosine 5′-monophosphate sodium salt also known as 9H-Purin-6-amine, N-methyl-9-(5-O-phosphonopentofuranosyl)-, sodium salt
Application:
N6-Methyladenosine 5′-monophosphate sodium salt is N6-Methyladenosine 5′-monophosphate sodium salt is an activator of PYGB (glycogen phosphorylase b)
CAS Number:
81921-35-9
Purity:
≥98%
Molecular Weight:
407.23
Molecular Formula:
C11H16N5O7P•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N6-Methyladenosine 5′-monophosphate sodium salt serves as a pivotal activator of glycogen phosphorylase b, playing a role in the modulation of glycogen metabolism by facilitating the conversion of glycogen to glucose-1-phosphate, a process essential for the mobilization of energy within cellular structures. Furthermore, this compound is instrumental in the realm of molecular biology research, particularly in N6-methyladenosine (m6A) ribonucleoprotein immunoprecipitation reactions. The significance of m6A in research cannot be overstated, as the modification of mRNA with m6A marks a fundamental mechanism influencing the stability and translational efficiency of mRNA molecules. This modification is a key epigenetic marker that aids in the regulation of gene expression at the post-transcriptional level, providing insights into the dynamic interplay between epigenetic modifications and gene expression. Consequently, N6-Methyladenosine 5′-monophosphate sodium salt is useful in the study of genetic regulation and the underlying mechanisms of gene expression modulation, offering profound implications for understanding the complexities of cellular function and genetic expression patterns.


N,[object Object],-Methyladenosine 5′-monophosphate sodium salt (CAS 81921-35-9) References

  1. N6-methyladenosine-dependent regulation of messenger RNA stability.  |  Wang, X., et al. 2014. Nature. 505: 117-20. PMID: 24284625
  2. Identification of Methylated Deoxyadenosines in Genomic DNA by dA6m DNA Immunoprecipitation.  |  Koziol, MJ., et al. 2016. Bio Protoc. 6: PMID: 28180135
  3. Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation.  |  Yoon, KJ., et al. 2017. Cell. 171: 877-889.e17. PMID: 28965759
  4. FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism.  |  Wu, R., et al. 2018. Biochim Biophys Acta Mol Cell Biol Lipids. 1863: 1323-1330. PMID: 30305247
  5. Dot Blot Analysis for Measuring Global N6-Methyladenosine Modification of RNA.  |  Nagarajan, A., et al. 2019. Methods Mol Biol. 1870: 263-271. PMID: 30539562
  6. WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.  |  Chen, Y., et al. 2019. Mol Cancer. 18: 127. PMID: 31438961
  7. YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness.  |  Han, B., et al. 2020. EMBO Rep. 21: e49229. PMID: 32064749
  8. HBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3-mediated m6A modification of HIF-1α.  |  Yang, N., et al. 2021. J Cell Physiol. 236: 3863-3880. PMID: 33305825
  9. Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC.  |  Ohshiro, T., et al. 2021. Sci Rep. 11: 19304. PMID: 34588546
  10. METTL3-Mediated N6-Methyladenosine Modification of Trim59 mRNA Protects Against Sepsis-Induced Acute Respiratory Distress Syndrome.  |  Chen, Y., et al. 2022. Front Immunol. 13: 897487. PMID: 35693774
  11. Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line.  |  Jiao, Y., et al. 2022. Nutr Metab Cardiovasc Dis. 32: 2655-2668. PMID: 36058761
  12. A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells.  |  Porman, AM., et al. 2022. PLoS Biol. 20: e3001885. PMID: 36441764
  13. Identification and comparison of m6A modifications in glioblastoma non-coding RNAs with MeRIP-seq and Nanopore dRNA-seq.  |  Krusnauskas, R., et al. 2023. Epigenetics. 18: 2163365. PMID: 36597408
  14. Effects of N6-methyladenosine on the synthesis of phenylethanolamine N-methyltransferase in cultured explants of rat adrenal medulla.  |  Burke, WJ. and Joh, TH. 1982. J Neurochem. 39: 92-6. PMID: 7086420
  15. AMP analogs: their function in the activation of glycogen phosphorylase b.  |  Morange, M., et al. 1976. Eur J Biochem. 65: 553-63. PMID: 949983

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N6-Methyladenosine 5′-monophosphate sodium salt, 5 mg

sc-215524A
5 mg
$166.00

N6-Methyladenosine 5′-monophosphate sodium salt, 10 mg

sc-215524B
10 mg
$249.00

N6-Methyladenosine 5′-monophosphate sodium salt, 25 mg

sc-215524
25 mg
$409.00

N6-Methyladenosine 5′-monophosphate sodium salt, 50 mg

sc-215524C
50 mg
$699.00

N6-Methyladenosine 5′-monophosphate sodium salt, 100 mg

sc-215524D
100 mg
$979.00