PI 4-kinase II β Activators
PI 4-kinase II β activators are a suite of chemical compounds that indirectly amplify the kinase's activity by influencing the cellular lipid environment and energy status. Phosphatidylinositol, the kinase's substrate, and ATP, the phosphate donor, are fundamental to PI 4-kinase II β's action, facilitating the synthesis of PI4P, a key lipid signaling molecule. Additional lipid molecules such as phosphatidic acid and dioleoylglycerol indirectly boost the kinase's activity by altering membrane composition and dynamics, potentially increasing substrate availability. Similarly, arachidonic acid modifies membrane properties to favor the kinase's function, while GTP and ceramide may enhance PI 4-kinase II β activity by stimulating membrane trafficking and altering lipid bilayer composition, respectively. Cholesterol's role in organizing lipid rafts also suggests a regulatory influence on the localization and activity of PI 4-kinase II β within these specialized membrane domains.
The activity of PI 4-kinase II β is further influenced by compounds that modulate secondary messenger systems. Forskolin and isoproterenol, both of which raise intracellular cAMP levels, indirectly enhance the kinase's activity by activating protein kinase A (PKA). PKA-mediated phosphorylation events can alter the demand for PI4P, thus stimulating PI 4-kinase II β function to meet the increased need for this lipid second messenger. Additionally, the beta-adrenergic effects of isoproterenol evoke changes in cAMP-dependent pathways that can indirectly upregulate the kinase's activity. Nicotinic acid, by contributing to NAD+ biosynthesis, may affect cellular processes that rely on PI4P, indirectly necessitating increased PI 4-kinase II β activity.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Phosphatidylinositol sodium salt | 383907-36-6 | sc-221821 | 10 mg | $408.00 | 1 | |
Phosphatidylinositol serves as a substrate for PI 4-kinase II β, and its availability directly increases the kinase's activity by providing the necessary molecules for phosphorylation at the D-4 position of the inositol ring, leading to the production of PI4P, a critical lipid second messenger. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP is the primary donor of the phosphate group in the kinase reaction catalyzed by PI 4-kinase II β. Higher concentrations of ATP can enhance the activity of PI 4-kinase II β by ensuring an ample supply of phosphate groups for the phosphorylation of phosphatidylinositol. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium levels, which can indirectly enhance PI 4-kinase II β activity as calcium ions may activate certain signaling pathways or cellular processes that utilize PI4P, thus creating a demand for PI 4-kinase II β activity. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DAG is involved in membrane signaling and can indirectly enhance the activity of PI 4-kinase II β by perturbing the membrane structure, possibly increasing the accessibility of the substrate to the kinase and enhancing the production of PI4P. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid can modulate membrane dynamics and may affect PI 4-kinase II β indirectly by modifying the lipid environment where the kinase is active, enhancing its functional activity through changes in membrane properties. | ||||||
Guanosine 5′-Triphosphate, Disodium Salt | 56001-37-7 | sc-295030 sc-295030A | 50 mg 250 mg | $166.00 $327.00 | ||
GTP is involved in signaling pathways and membrane trafficking. An increase in GTP-bound proteins can indirectly enhance PI 4-kinase II β activity by promoting membrane trafficking events that require PI4P, thus stimulating kinase activity. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide influences membrane properties and could enhance PI 4-kinase II β activity by altering the lipid bilayer's composition, thereby impacting the kinase's membrane association and subsequent activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which may indirectly enhance PI 4-kinase II β activity by activating PKA. PKA phosphorylation of certain proteins can lead to downstream effects that increase the demand for PI4P, thus indirectly enhancing the kinase's activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
As a beta-adrenergic agonist, Isoproterenol increases cAMP levels, indirectly enhancing PI 4-kinase II β activity via PKA activation, which can affect the demand for PI4P in signaling pathways where PI 4-kinase II β is active. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic acid, as a precursor to NAD+, can indirectly influence PI 4-kinase II β activity. Higher levels of NAD+ may enhance cellular processes that depend on PI4P, thereby increasing the functional demand for PI 4-kinase II β's activity. | ||||||