PI 4-kinase II β Inhibitors
Chemical inhibitors of PI 4-kinase II β include a range of compounds that functionally impede the activity of this enzyme by targeting various aspects of the phosphoinositide signaling pathway. Wortmannin and LY294002 are notable examples that inhibit phosphoinositide 3-kinases (PI3K), which are upstream of PI 4-kinase II β in the signaling cascade. By inhibiting PI3K, these chemicals lead to a reduction in the production of phosphatidylinositol 4-phosphate (PI(4)P), the direct product of PI 4-kinase II β action. In a similar vein, PIK-93, though initially recognized as a PI4KIIIβ inhibitor, can reduce PI(4)P levels, thereby inhibiting PI 4-kinase II β by limiting its substrate availability. Inhibitor 2, a pyrimidine derivative, directly targets PI 4-kinase II β, obstructing its kinase activity which results in decreased PI(4)P synthesis.
Additionally, phenylarsine oxide (PAO) indirectly inhibits PI 4-kinase II β by altering the phosphorylation status of proteins that regulate the kinase's activity. GW5074, a Raf kinase inhibitor, disrupts the Ras/Raf/MEK/ERK signaling pathway, which is connected to phosphoinositide signaling, thus indirectly affecting PI 4-kinase II β. Miltefosine, an alkylphosphocholine, and A-443654, an Akt inhibitor, both disrupt downstream signaling of the PI3K/AKT pathway, leading to an indirect functional inhibition of PI 4-kinase II β. BX-912 and IC87114, inhibitors of PDK1 and PI3Kδ respectively, impede upstream signaling necessary for PI 4-kinase II β activation. Furthermore, TGX-221, a PI3Kβ inhibitor, and CAL-101, another PI3Kδ inhibitor, contribute to the inhibition by preventing the signaling that would normally result in PI 4-kinase II β-mediated synthesis of PI(4)P, thus effectively inhibiting the enzyme's function within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite of fungi that acts as a potent inhibitor of phosphoinositide 3-kinases (PI3K). PI 4-kinase II β, being a kinase involved in phosphoinositide signaling, could be functionally inhibited by Wortmannin's action on the PI3K pathway, leading to a decrease in phosphatidylinositol 4-phosphate synthesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific chemical inhibitor of PI3Ks. By inhibiting PI3K, LY294002 can reduce the overall phosphoinositide signaling, which includes the activity of PI 4-kinase II β, leading to a reduction in the production of phosphatidylinositol 4-phosphate. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is known to inhibit PI4KIIIβ, and its action can extend to PI 4-kinase II β by reducing the levels of PI(4)P, which is a product of PI 4-kinase II β activity, thereby functionally inhibiting the kinase's activity. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine oxide (PAO) is an organoarsenic compound that inhibits protein tyrosine phosphatases. By altering the phosphorylation status of proteins, PAO can indirectly inhibit PI 4-kinase II β by affecting the proteins that regulate PI 4-kinase II β activity. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a Raf kinase inhibitor that can indirectly inhibit PI 4-kinase II β by disrupting the Ras/Raf/MEK/ERK signaling pathway, which is interconnected with phosphoinositide signaling pathways. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $79.00 | 8 | |
Miltefosine is a choline analog that inhibits PI3K/AKT signaling and could thereby indirectly inhibit PI 4-kinase II β activity by disrupting downstream phosphoinositide signaling and reducing substrate availability. | ||||||
A-443654 | 552325-16-3 | sc-507339 | 1 mg | $140.00 | ||
A-443654 is an Akt inhibitor that indirectly inhibits PI 4-kinase II β by reducing PI3K/AKT pathway signaling, which is necessary for the full activation of many kinases in the phosphoinositide signaling pathways. | ||||||
IC-87114 | 371242-69-2 | sc-364509 sc-364509A | 5 mg 50 mg | $140.00 $1060.00 | 1 | |
IC87114 is a selective PI3Kδ inhibitor that can indirectly inhibit PI 4-kinase II β by disrupting the PI3Kδ signaling, which could diminish the kinase's activity in signaling cascades that produce PI(4)P. | ||||||
PI 3-Kβ Inhibitor VI, TGX-221 | 663619-89-4 | sc-203190 | 1 mg | $437.00 | ||
TGX-221 is a selective PI3Kβ inhibitor. As PI 4-kinase II β operates within the PI3K-related pathways, inhibition of PI3Kβ can lead to reduced PI(4)P synthesis by functionally inhibiting PI 4-kinase II β. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $189.00 | 4 | |
CAL-101 (Idelalisib) is a selective inhibitor of PI3Kδ. It could indirectly inhibit PI 4-kinase II β by impairing the PI3Kδ signaling, which is part of the phosphoinositide signaling network that includes PI 4-kinase II β. | ||||||