Molecular structure of PI 3-Kβ Inhibitor VI, TGX-221, CAS Number: 663619-89-4
PI 3-Kβ Inhibitor VI, TGX-221 (CAS 663619-89-4)
Application:
PI 3-Kβ Inhibitor VI, TGX-221 is a reversible ATP-competitive inhibitor of PI 3-kinase β
CAS Number:
663619-89-4
Purity:
>97%
Molecular Weight:
364.4
Molecular Formula:
C21H24N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
PI 3-Kβ Inhibitor VI, TGX-221 is a cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kb (IC50 = 0.005, 0.1, 5, and ≥3.5 µM for -b, -d, -a and -g isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110b-dependent responses in cells in vitro .
Inhibitor of:
β-defensin 133, C230055K05Rik, C230072F16Rik, DIP2C, DYNC2LI1, E230008N13Rik, G-CSFR, GCET2, IRS-4, LIN-44, Lyn, PI 3-kinase C2α, PI 3-kinase C2β, PI 3-kinase C2y, PI 3-kinase p101, PI 3-kinase p110, PI 3-kinase p110 beta, PI 3-kinase p85α, PI 3-kinase p85γ, PI 4-kinase II β, PIP2, PIPK I β, PIPK II β, SNX31, TMEM55B, TPIP, and ZNF883.Activator of:
CARD 11, Clm3, Gab 2, MTMR2, NDR1, PI 3-kinase p55γ, and SDF-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PI 3-Kβ Inhibitor VI, TGX-221, 1 mg | sc-203190 | 1 mg | $437.00 |