Molecular structure of IC-87114, CAS Number: 371242-69-2
IC-87114 (CAS 371242-69-2)
See product citations (1)
Alternate Names:
2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
Application:
IC-87114 is a PI3K inhibitor with action against fMLP-PIP3
CAS Number:
371242-69-2
Purity:
≥98%
Molecular Weight:
397.43
Molecular Formula:
C22H19N7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IC-87114 selectively inhibits PI3Kδ, and is not sensitive to PI3Kα, β, or γ. In human neutrophils, IC-87114 (5 µM) potently inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated phosphatidylinositol triphosphate (PIP3) biosynthesis and chemotaxis. In human acute myeloid leukemia (AML) blast cells, such as bone marrow mononuclear cells (BMMCs), IC-87114 (10 µM) inhibits both constitutive and Flt-3-stimulated Akt phosphorylation and cell proliferation. It is also found that IC-87114 (5 µM–30 µM) inhibits SCF- or IL-3-stimulated BMMC responses, which are not observed in PI3Kδ mutant (p110δD910A) cells.
Inhibitor of:
C2orf18, C2orf74_1700093K21Rik, C6orf103, INPP5J, Pellino 2, PI 3-kinase, PI 3-kinase C2α, PI 3-kinase C2y, PI 3-kinase p110 delta, PI 3-kinase p85α, PI 4-kinase II β, PIP2, PIPK I β, PIPK II β, PIPK II γ, SNX31, Synaptotagmin VIII, Synaptotagmin XIII, and TMEM55B.Activator of:
PI 3-kinase C2β, PI 3-kinase p55γ, and SMC1α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IC-87114, 5 mg | sc-364509 | 5 mg | $140.00 | |||
IC-87114, 50 mg | sc-364509A | 50 mg | $1060.00 |