L-type Ca++ CP γ5 Activators
Dihydropyridines such as nifedipine, amlodipine, and their analogs like isradipine, nicardipine, cilnidipine, levamlodipine, felodipine, lacidipine, and manidipine stand out for their ability to bind selectively to L-type calcium channels. These compounds typically function as antagonists but can exhibit a dual role by stabilizing the channels in a configuration that promotes calcium flow when applied in doses below their typical blocking threshold. This stabilization can lead to an increase in channel availability, potentially enhancing the channel's responsiveness to electrical stimuli.
Bay K 8644 distinctly differs from the aforementioned dihydropyridines due to its agonist properties, actively increasing the calcium current through L-type channels, thus directly modulating the channel activity. On the other hand, the benzothiazepine diltiazem and the phenylalkylamine verapamil, while also classified as calcium channel blockers, engage with L-type channels in a different manner. They are particularly influential in the inactivation kinetics of the channels, which can result in an overall upregulation of channel activity and calcium conductance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
A dihydropyridine calcium channel blocker that can increase calcium channel availability by preventing excessive inactivation when used in sub-blocking concentrations. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Another dihydropyridine that acts similarly to nifedipine and can modulate channel availability and function. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
A dihydropyridine that acts as a calcium channel agonist, increasing calcium current through L-type channels. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $88.00 $324.00 | 1 | |
A calcium channel antagonist which at sub-blocking doses can stabilize the open state of the channel. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
A benzothiazepine that can enhance the activity of calcium channels by affecting their inactivation kinetics. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
A phenylalkylamine that interacts with L-type channels, potentially affecting the gating mechanisms and increasing channel activity. | ||||||
Cilnidipine | 132203-70-4 | sc-201485 sc-201485A sc-201485B | 10 mg 50 mg 1 g | $74.00 $284.00 $450.00 | 1 | |
A dual L-type and N-type calcium channel blocker that may improve the function of L-type channels at subtherapeutic concentrations. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $91.00 $222.00 | 1 | |
Another dihydropyridine that can stabilize L-type calcium channels in a state that allows for regulated calcium influx. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
A calcium channel antagonist that can upregulate channel density or responsiveness through feedback mechanisms. | ||||||
Manidipine | 89226-50-6 | sc-211774 | 10 mg | $278.00 | ||
Has a unique binding site on L-type channels and can alter channel conductance and kinetics. | ||||||