Molecular structure of Manidipine, CAS Number: 89226-50-6
Manidipine (CAS 89226-50-6)
Alternate Names:
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester
Application:
Manidipine is a calcium channel protein inhibitor and antagonist
CAS Number:
89226-50-6
Molecular Weight:
610.70
Molecular Formula:
C35H38N4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Manidipine is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound.
Manidipine (CAS 89226-50-6) References
- Manidipine: a review of its use in the management of hypertension. | McKeage, K. and Scott, LJ. 2004. Drugs. 64: 1923-40. PMID: 15329044
- Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage. | Coca, A. 2007. Expert Rev Cardiovasc Ther. 5: 147-59. PMID: 17338661
- Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland. | Ito, T., et al. 1992. Cancer Res. 52: 1369-71. PMID: 1737400
- Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. | Costa, S., et al. 2010. Pharmacol Res. 62: 265-70. PMID: 20347984
- Manidipine treatment in patients with albuminuria not sufficiently reduced with renin-angiotensin system blockers. | Galceran, J., et al. 2010. Expert Rev Cardiovasc Ther. 8: 751-7. PMID: 20528630
- Effects of manidipine and its combination with an ACE inhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markers in hypertensive patients with metabolic syndrome: the MARCADOR study. | Martinez-Martin, FJ., et al. 2011. Clin Drug Investig. 31: 201-12. PMID: 21155616
- Vascular and metabolic properties of manidipine. | Buset Ríos, N., et al. 2011. Nefrologia. 31: 268-74. PMID: 21407275
- Treatment of hypertensive patients with diabetes: beyond blood pressure control and focus on manidipine. | Saiz Satjes, M. and Martinez-Martin, FJ. 2016. Future Cardiol. 12: 435-47. PMID: 27221471
- Manidipine: an antihypertensive drug with positive effects on metabolic parameters and adrenergic tone in patients with diabetes. | SaizSatjes, M. and Martinez-Martin, FJ. 2018. Drugs Context. 7: 212509. PMID: 29344052
- New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect. | Meguro, K., et al. 1985. Chem Pharm Bull (Tokyo). 33: 3787-97. PMID: 4092280
Inhibitor of:
CA II, CA XI, CaBP2, Cacna2d4, Calcium Channel Protein, CLCA2_Clac2, L-type Ca++ CP α1C, L-type Ca++ CP α1S, L-type Ca++ CP β2, L-type Ca++ CP β4, L-type Ca++ CP γ2, Olr1432, and Olr1470.Activator of:
L-type Ca++ CP γ4, L-type Ca++ CP γ5, and L-type calcium channel α1C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Manidipine, 10 mg | sc-211774 | 10 mg | $278.00 |