Molecular structure of Cilnidipine, CAS Number: 132203-70-4
Cilnidipine (CAS 132203-70-4)
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Alternate Names:
FRC 8653
Application:
Cilnidipine is an L-/N-type calcium channel protein inhibitor and blocker
CAS Number:
132203-70-4
Purity:
≥98%
Molecular Weight:
492.5
Molecular Formula:
C27H28N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cilnidipine is a dihydropyridine calcium channel blocker that functions by inhibiting the influx of calcium ions into smooth muscle cells and cardiac myocytes. This inhibition leads to the relaxation of vascular smooth muscle and a reduction in systemic vascular resistance. Cilnidipine exerts its mode of action by selectively blocking L-type calcium channels, which are predominantly found in vascular smooth muscle and the heart. By blocking these channels, cilnidipine prevents the influx of calcium ions, thereby inhibiting muscle contraction and promoting vasodilation. This mechanism of action results in decreased blood pressure and improved blood flow to the heart and other organs. Cilnidipine may possess antioxidant properties, which may contribute to its effects.
Cilnidipine (CAS 132203-70-4) References
- Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C. | Löhn, M., et al. 2002. J Hypertens. 20: 885-93. PMID: 12011649
- Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model. | Takahara, A., et al. 2004. Biol Pharm Bull. 27: 1388-91. PMID: 15340224
- Ca2+ channel subtypes and pharmacology in the kidney. | Hayashi, K., et al. 2007. Circ Res. 100: 342-53. PMID: 17307972
- Renal and vascular protective effects of cilnidipine in patients with essential hypertension. | Morimoto, S., et al. 2007. J Hypertens. 25: 2178-83. PMID: 17885563
- Cilnidipine: a new generation Ca channel blocker with inhibitory action on sympathetic neurotransmitter release. | Takahara, A. 2009. Cardiovasc Ther. 27: 124-39. PMID: 19426250
- Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway. | Lee, YJ., et al. 2009. J Neurochem. 111: 90-100. PMID: 19650875
- Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus. | Masuda, T., et al. 2011. Cardiovasc Ther. 29: 46-53. PMID: 20337636
- Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel. | Shimizu, H., et al. 2012. Hypertens Res. 35: 77-81. PMID: 21881574
- Cilnidipine regulates glucose metabolism and levels of high-molecular adiponectin in diet-induced obese mice. | Ueno, D., et al. 2013. Hypertens Res. 36: 196-201. PMID: 23051658
- Role of P-glycoprotein in regulating cilnidipine distribution to intact and ischemic brain. | Yano, K., et al. 2014. Drug Metab Pharmacokinet. 29: 254-8. PMID: 24366438
- The fourth-generation Calcium channel blocker: cilnidipine. | Chandra, KS. and Ramesh, G. 2013. Indian Heart J. 65: 691-5. PMID: 24407539
- Pretreatment with cilnidipine attenuates hypoxia/reoxygenation injury in HL-1 cardiomyocytes through enhanced NO production and action potential shortening. | Minato, H., et al. 2020. Hypertens Res. 43: 380-388. PMID: 31942044
- Cilnidipine and magnesium sulfate supplement ameliorates hyperglycemia, dyslipidemia and inhibits oxidative-stress in fructose-induced diabetic rats. | Khatun Kali, MS., et al. 2022. Heliyon. 8: e08671. PMID: 35028456
Inhibitor of:
ABC-1, CA XI, Calcium Channel Protein, CAPS-2, FOXP1, L-type Ca++ CP α1S, Olr1413, Olr424, and ZO-1.Activator of:
L-type Ca++ CP β2, L-type Ca++ CP γ2, L-type Ca++ CP γ4, L-type Ca++ CP γ5, L-type Ca++ CP γ7, N-type calcium channel α1B, S-100A3, and SCG10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cilnidipine, 10 mg | sc-201485 | 10 mg | $74.00 | |||
Cilnidipine, 50 mg | sc-201485A | 50 mg | $284.00 | |||
Cilnidipine, 1 g | sc-201485B | 1 g | $450.00 |