FAM83C Activators
Family with sequence similarity 83, member C (FAM83C), is a protein that, as its name suggests, belongs to the FAM83 protein family, characterized by a conserved domain of unknown function, DUF1669. FAM83C is believed to play a role in cellular processes such as proliferation and differentiation, and it has captured the interest of researchers due to its potential involvement in the pathology of certain types of cancer.The FAM83C protein is encoded by the FAM83C gene and has been identified as a potential oncogene in various studies. It has been observed to be overexpressed in certain carcinomas, which suggests that it might contribute to tumorigenesis, likely through the dysregulation of signaling pathways that control cell division and growth. The molecular mechanisms through which FAM83C exerts its effects, however, are not fully understood.
Research has indicated that FAM83C may interact with components of key signaling pathways, such as the PI3K/AKT/mTOR pathway, which is known for its role in regulating cell survival, protein synthesis, and metabolism. These interactions may lead to aberrant activation of the pathway, contributing to the uncontrolled cell growth characteristic of cancerous tissues.The specific function of the DUF1669 domain within FAM83C remains a mystery. It is possible that this domain mediates protein-protein interactions that are critical for the regulatory roles the protein might have in signaling cascades. Further research into the structure and binding partners of FAM83C could provide insights into the domain's function and the protein's overall role in cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, can activate retinoic acid receptors (RARs) which may enhance the transcription of FAM83C by binding to retinoic acid response elements in its promoter region. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol found in green tea, may influence gene expression through epigenetic modifications. This can lead to the upregulation of FAM83C expression by altering chromatin structure. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, can increase the acetylation of histones, resulting in a more relaxed chromatin structure that may facilitate the transcription of FAM83C. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor, it can reduce DNA methylation levels, potentially leading to the demethylation and activation of the FAM83C gene promoter. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane modulates histone deacetylase activity, which could lead to changes in the chromatin state of the FAM83C gene, enhancing its transcription. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate transcription factors, possibly resulting in the increased transcription of FAM83C. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can inhibit GSK-3, leading to stabilization and activation of β-catenin which may bind to and activate transcription factors that enhance FAM83C gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate may increase histone acetylation, promoting a transcriptionally active chromatin state and potentially upregulating FAM83C expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may activate sirtuin 1, leading to deacetylation of transcription factors or coactivators involved in the transcriptional activation of FAM83C. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, through its active form, calcitriol, can bind to the vitamin D receptor. The receptor-ligand complex may then enhance the transcription of FAM83C by interacting with vitamin D response elements. | ||||||