cystatin 12 Activators
Cst12, known as cystatin 12, emerges as a key player in cellular processes with its predicted function as an inhibitor of cysteine-type endopeptidases. Positioned to act upstream of negative regulation of peptidase activity, this gene is anticipated to exert its influence within the extracellular region, particularly notable for its expression in the reproductive system. The orthologous relationship with human CST12P further underscores the evolutionary conservation of its functional significance. As a cysteine protease inhibitor, Cst12 plays a vital role in maintaining cellular homeostasis by modulating the activity of cysteine-type endopeptidases, key enzymes involved in various cellular processes.
The activation of Cst12 involves a sophisticated interplay of molecular mechanisms orchestrated by a variety of chemical activators. The gene can be directly activated through the inhibition of histone deacetylation and DNA methylation, leading to an open chromatin structure that facilitates enhanced transcription. Indirect activation pathways encompass the inhibition of critical signaling pathways such as TGF-β, MAPK/ERK, PI3K/AKT, NF-κB, STAT3, JAK/STAT, Wnt, PI3K/mTOR, and Notch. By blocking these pathways, negative regulation on Cst12 is alleviated, allowing for increased gene expression and subsequent upregulation. This intricate regulatory network highlights the versatility and adaptability of Cst12 in responding to diverse environmental cues, emphasizing its significance in maintaining cellular integrity and modulating key cellular processes. Exploring the comprehensive landscape of Cst12 and its activation mechanisms contributes not only to our understanding of its role in cellular function but also provides a foundation for potential implications in broader biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, directly activates Cst12 by inhibiting histone deacetylation, promoting an open chromatin structure and facilitating enhanced Cst12 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, directly activates Cst12 by influencing DNA demethylation, leading to a demethylated state in the gene promoter and enhanced Cst12 transcription. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β Receptor Inhibitor, indirectly stimulates Cst12 by blocking the TGF-β signaling pathway, alleviating negative regulation and promoting increased Cst12 expression and subsequent upregulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, an HDAC Inhibitor, directly activates Cst12 by inhibiting histone deacetylation, fostering an open chromatin structure that enhances Cst12 expression and facilitates its upregulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MAPK/ERK Inhibitor, indirectly activates Cst12 by blocking the MAPK/ERK pathway, relieving negative regulation and leading to increased Cst12 expression and subsequent upregulation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K Inhibitor, indirectly stimulates Cst12 by blocking the PI3K/AKT pathway, alleviating negative regulation and promoting enhanced Cst12 expression and subsequent upregulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an NF-κB Inhibitor, indirectly activates Cst12 by inhibiting the NF-κB pathway, relieving negative regulation and enhancing Cst12 expression, contributing to its upregulation. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
Stattic, a STAT3 Inhibitor, indirectly stimulates Cst12 by blocking the STAT3 pathway, alleviating negative regulation and promoting increased Cst12 expression and subsequent upregulation. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib, a JAK Inhibitor, indirectly activates Cst12 by blocking the JAK/STAT pathway, relieving negative regulation and facilitating enhanced Cst12 expression and subsequent upregulation. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939, a Wnt Pathway Inhibitor, indirectly stimulates Cst12 by blocking the Wnt signaling pathway, alleviating negative regulation and promoting increased Cst12 expression and upregulation. | ||||||