CYP39A1 Activators
CYP39A1 activators refers to compounds that indirectly influence the activity of CYP39A1. They operate primarily through induction mechanisms involving nuclear receptor activation. Rifampicin and phenobarbital, for instance, act on nuclear receptors such as PXR and CAR, which can bind to DNA response elements to increase the transcription of CYP39A1. Retinoic acid, through retinoic acid receptors, may enhance the transcription of genes, possibly including those encoding CYP39A1, leading to increased protein levels.
Some compounds, like forskolin, raise intracellular cAMP, which might activate a cascade leading to enhanced CYP39A1 transcription. Glucocorticoids such as dexamethasone can increase the expression of various CYP enzymes via the glucocorticoid receptor; a similar mechanism may operate for CYP39A1. PPAR agonists like pioglitazone and clofibrate have the ability to modify the transcriptional landscape of cells, influencing the expression of genes involved in lipid metabolism, which may include CYP39A1. Furthermore, the presence of substrates such as cholesterol and pregnenolone can induce the expression of CYP39A1 through substrate-induced transcriptional regulation. Allicin from garlic extract and capsaicin might affect the enzyme as part of a more general response to dietary components or xenobiotics, likely involving the activation of transcription factors like Nrf2, which responds to oxidative stress and may influence the expression of detoxifying enzymes, including CYP39A1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol can increase CYP39A1 expression by acting as a substrate for the enzyme, leading to a substrate-induced upregulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences gene transcription through retinoic acid receptors that may include genes encoding CYP39A1, thus enhancing its levels. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Acts on nuclear receptors such as PXR, leading to increased transcription and expression of CYP39A1. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $87.00 $148.00 $347.00 $1122.00 | ||
As a steroid precursor, it may signal the need for CYP39A1's role in steroid metabolism, potentially increasing its expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP, which can upregulate CYP39A1 through cAMP-dependent pathways that increase transcription of P450 enzymes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoids can induce CYP enzyme expression via glucocorticoid receptor activation; may include CYP39A1. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Through PPAR-gamma activation, can upregulate genes involved in lipid metabolism, potentially including CYP39A1. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
May induce CYP39A1 by affecting nuclear receptors like PXR which increases transcription of P450 enzymes. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Activates PPAR alpha, which may enhance the transcription of genes involved in fatty acid metabolism, including CYP39A1. | ||||||
Allicin | 539-86-6 | sc-202449 sc-202449A | 1 mg 5 mg | $489.00 $1557.00 | 7 | |
Known to modulate P450 enzyme expression possibly through Nrf2 pathway activation, which could include CYP39A1. | ||||||