CYP39A1 Inhibitors
CYP39A1 inhibitors are a collection of compounds that can inhibit the P450 enzymes through various mechanisms, offering a range of avenues through which CYP39A1's activity can be modulated. For instance, compounds like Ketoconazole, Fluconazole, and Miconazole function by binding to the heme-iron center, which is crucial for the enzymatic activity of the P450 proteins. By interacting with this center, these compounds effectively reduce the activity of the enzymes, including CYP39A1.
Other compounds in this class, such as Cimetidine, Quinidine, and Diltiazem, act by competing with substrates for the enzyme's active site. Their presence can hinder the binding of natural substrates, thereby suppressing the enzyme's activity. Another mechanism is employed by antibiotics like Chloramphenicol and Erythromycin. These compounds can bind to the active site of the enzyme, disrupting its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
An antifungal drug that inhibits multiple cytochrome P450 isoenzymes. It can reduce CYP39A1 activity by binding to its heme-iron center. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Another antifungal that has known inhibitory effects on several P450 enzymes, including those in the CYP3A and CYP2C families. Its influence on CYP39A1 can arise from similar mechanisms. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
This drug is known to inhibit various cytochrome P450 enzymes by competing with substrates for binding. It can affect CYP39A1 through a similar mechanism. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
An antibiotic that inhibits various cytochrome P450 enzymes. It can bind to the active site of CYP39A1, reducing its activity. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
An antiarrhythmic drug that inhibits several cytochrome P450 enzymes. Its inhibitory effect on CYP39A1 can be due to competition for the enzyme's active site. | ||||||
Ticlopidine Hydrochloride | 53885-35-1 | sc-205861 sc-205861A | 1 g 5 g | $31.00 $97.00 | 2 | |
An antiplatelet drug that inhibits various P450 enzymes. It can bind to CYP39A1, reducing its activity. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
An antifungal drug that can inhibit several cytochrome P450 enzymes. It acts by interacting with the heme group, which can affect CYP39A1 activity. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
An antibiotic that can inhibit various cytochrome P450 enzymes. Its mechanism involves binding to the active site, which can influence CYP39A1. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
A calcium channel blocker that inhibits several P450 enzymes. It can reduce CYP39A1 activity through competitive binding. | ||||||