ALG2 Activators
Chemicals classified as ALG2 Activators primarily target calcium homeostasis to activate ALG2. For example Cyclopiazonic Acid, and A23187 directly manipulate calcium levels by either inhibiting SERCA or acting as calcium ionophores, thus influencing ALG2 activation through calcium binding. Additionally, certain compounds like 2-APB and Nifedipine work in a more convoluted manner. While they inhibit specific calcium channels or receptors, their actions result in an overall increase in cytosolic calcium through store-operated channels, thereby activating ALG2.
Other compounds such as Dantrolene and Ryanodine focus on ryanodine receptors to change calcium homeostasis. By either inhibiting or locking these receptors in a sub-conductance state, they increase cytosolic calcium, allowing ALG2 to bind calcium more effectively. Meanwhile, BTP2 disrupts calcium efflux by inhibiting CRAC channels, thus raising cytosolic calcium levels and activating ALG2. These chemicals represent a portfolio of targeted approaches to alter calcium dynamics and influence ALG2 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, thereby binding to ALG2 and activating it. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is an inositol trisphosphate (IP3) receptor inhibitor. It blocks calcium release through the IP3 pathway but paradoxically increases calcium influx through store-operated channels, thereby activating ALG2. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium and activating ALG2 through calcium binding. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is an L-type calcium channel blocker, but it indirectly increases intracellular calcium through the activation of store-operated calcium entry, hence activating ALG2. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil blocks voltage-gated calcium channels, causing an indirect elevation of intracellular calcium via store-operated calcium entry channels, which can activate ALG2. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator that can paradoxically increase intracellular calcium by stimulating calcium influx mechanisms, which can lead to ALG2 activation. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, leading to altered calcium homeostasis. This can result in increased availability of calcium for ALG2 binding and activation. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is another SERCA inhibitor like Thapsigargin, raising cytosolic calcium levels and consequently activating ALG2. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine locks ryanodine receptors in a sub-conductance state, increasing calcium levels in the cytosol, thus activating ALG2. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $189.00 | 9 | |
BTP2 is an inhibitor of CRAC (Calcium Release-Activated Calcium) channels. It increases cytosolic calcium by disrupting calcium efflux, thereby activating ALG2. | ||||||