MEAF6 Activators
MEAF6 Activators are a collection of chemical compounds that are believed to influence the function of MEAF6, a protein critical in histone acetylation as part of the NuA4 histone acetyltransferase complex. Thesecompounds primarily work by modulating the acetylation state of proteins, given that histone acetylation is a key process that MEAF6 is involved in. Especially, many of these compounds, such as Trichostatin A and SAHA, function as inhibitors of histone deacetylases (HDACs). By inhibiting HDACs, these compounds enhance histone acetylation, which can potentially increase the functional activity of MEAF6.
On the other hand, compounds like Anacardic Acid, Garcinol, and C646 are histone acetyltransferase (HAT) inhibitors. While they generally reduce acetylation, they could cause a greater dependency on the remaining active HATs, such as the NuA4 complex that includes MEAF6, thereby indirectly enhancing its activity. Also, some compounds, like Nicotinamide, function by inhibiting specific proteins like SIRT1, which indirectly enhances histone acetylation and potentially the activity of MEAF6. Therefore, the primary biochemical pathways these compounds influence are those involving the acetylation and deacetylation of histones, with the ultimate result being the potential enhancement of MEAF6's functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound, can affect the acetylation state of proteins, a process relevant to MEAF6, which is part of the NuA4 histone acetyltransferase complex. Specifically, curcumin can inhibit HDACs and enhance histone acetylation, which may enhance MEAF6's acetyltransferase activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a HDAC inhibitor that can enhance acetylation of histones, a process that MEAF6 is involved in as a part of the NuA4 histone acetyltransferase complex. With HDAC activity reduced, acetylation is enhanced, potentially increasing MEAF6 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a HDAC inhibitor that can enhance histone acetylation, a process that MEAF6, being a part of the NuA4 histone acetyltransferase complex, is involved in. By inhibiting HDACs, SAHA can enhance MEAF6's acetyltransferase activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a SIRT1 inhibitor that can indirectly enhance acetylation of histones, a process in which MEAF6 is involved as part of the NuA4 histone acetyltransferase complex. With SIRT1 inhibited, acetylation is enhanced, potentially increasing MEAF6 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a HDAC inhibitor that enhances histone acetylation, a process that MEAF6, as part of the NuA4 histone acetyltransferase complex, is involved in. By inhibiting HDACs, sodium butyrate can enhance MEAF6's acetyltransferase activity. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid is a non-specific inhibitor of histone acetyltransferases (HATs). While this can generally reduce acetylation, it may put a greater dependency on the remaining HATs, including the NuA4 complex that includes MEAF6, thus indirectly enhancing its activity. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Garcinol is a HAT inhibitor that, by reducing overall acetylation, can lead to greater dependency on the remaining active HATs, such as the NuA4 complex that includes MEAF6, potentially enhancing its activity. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a competitive HAT inhibitor. By reducing overall acetylation, it can lead to a greater dependency on the remaining active HATs, such as the NuA4 complex that includes MEAF6, potentially enhancing its activity. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
RGFP966 is a HDAC3-specific inhibitor that can enhance histone acetylation, a process that MEAF6, as a part of the NuA4 histone acetyltransferase complex, is involved in. By inhibiting HDAC3, RGFP966 can enhance MEAF6's acetyltransferase activity. | ||||||
Tubastatin A | 1252003-15-8 | sc-507298 | 10 mg | $114.00 | ||
Tubastatin A is a HDAC6 inhibitor that can enhance histone acetylation, a process that MEAF6, being part of the NuA4 histone acetyltransferase complex, is involved in. By inhibiting HDAC6, Tubastatin A can enhance MEAF6's acetyltransferase activity. | ||||||