Molecular structure of Tubastatin A, CAS Number: 1252003-15-8
Tubastatin A (CAS 1252003-15-8)
Alternate Names:
N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-benzamide
CAS Number:
1252003-15-8
Molecular Weight:
335.4
Molecular Formula:
C20H21N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Tubastatin A (CAS 1252003-15-8) References
- Tubastatin A/ACY-1215 improves cognition in Alzheimer's disease transgenic mice. | Zhang, L., et al. 2014. J Alzheimers Dis. 41: 1193-205. PMID: 24844691
- Effect of Tubastatin A on the Functional Recovery of Cauda Equina Injury in Rats. | Fu, Z., et al. 2018. World Neurosurg. 114: e35-e41. PMID: 29408594
- Tubastatin A, an inhibitor of HDAC6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells. | Urdiciain, A., et al. 2019. Int J Oncol. 54: 1797-1808. PMID: 30864703
- Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes. | Choi, YJ., et al. 2019. Aging (Albany NY). 11: 1759-1777. PMID: 30913540
- Inhibition of HDAC6 by tubastatin A disrupts mouse oocyte meiosis via regulating histone modifications and mRNA expression. | Sui, L., et al. 2020. J Cell Physiol. 235: 7030-7042. PMID: 32017059
- Tubastatin A, a deacetylase inhibitor, as a tool to study the division, cell cycle and microtubule cytoskeleton of trypanosomatids. | de Oliveira Santos, J., et al. 2021. Eur J Protistol. 80: 125821. PMID: 34144311
- Tubastatin A suppresses the proliferation of fibroblasts in epidural fibrosis through phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway. | Liu, Y., et al. 2022. J Pharm Pharmacol.. PMID: 35230444
- Effects of tubastatin A on adrenocorticotropic hormone synthesis and proliferation of AtT-20 corticotroph tumor cells. | Hagiwara, R., et al. 2022. Endocr J. 69: 1053-1060. PMID: 35296577
- Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy. | Yang, J., et al. 2022. Sci Transl Med. 14: eabl5654. PMID: 35857625
- Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations. | Le Dour, C., et al. 2022. Nat Commun. 13: 7886. PMID: 36550158
Inhibitor of:
Cytokeratin 15, DNHD2, EG408191, HDA2, HDAC1, HDAC10, HDAC11, HDAC4, HDAC5, Histone cluster 3 H3, Histone H10, Histone H2B, Histone H3, HUD, OTTMUSG00000016781, OTTMUSG00000016783, SDS3, SUMO-2, and ZSCAN4B.Activator of:
EG546205, ELP3, HDA1, HDA6, Histone cluster 1 H4G, KNDC1, Lamin A, MEAF6, ZNF322A, and zygin 1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tubastatin A, 10 mg | sc-507298 | 10 mg | $112.00 |