ZUD_UNC5CL Inhibitors
ZUD_UNC5CL Inhibitors provides avenues to influence a myriad of intracellular events. Central to this class are inhibitors that target pivotal signaling modules like the PI3K/Akt, MAPK/ERK, and JNK pathways. LY294002 and Wortmannin, for instance, are potent PI3K inhibitors that can affect the cellular survival, growth, and proliferation signals mediated by Akt.
On the front of the MAPK cascade, PD98059 selectively halts MEK1, preventing ERK activation. This is complemented by SP600125 and SB203580, which target JNK and P38 MAPK respectively, addressing stress and inflammatory responses. Calcium signaling, vital for various cell functions, can be manipulated using U73122 and BAPTA-AM, the former stalling phospholipase C and the latter acting as an intracellular calcium sponge. Further influencing cell dynamics, Y-27632 inhibits ROCK, a kinase instrumental in cytoskeletal remodeling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibitor of PI3K, affecting downstream Akt signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK1, a component of the MAPK/ERK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor, impacting the MAPK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
P38 MAPK inhibitor. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor, stronger and less reversible than LY294002. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase (MLCK). | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK, impacting cytoskeleton dynamics. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Intracellular calcium chelator. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Broad-spectrum PKC inhibitor. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
Inhibits Wnt processing, decreasing Wnt secretion. | ||||||