ZSCAN18 Activators
Given the established function of ZSCAN18 in RNA polymerase II-specific transcriptional processes, activators for this transcription factor are primarily focused on agents capable of modulating gene expression, either by direct interference or through epigenetic alterations. Such agents like Retinoic Acid, Trichostatin A, and 5-Aza-2'-deoxycytidine exert control at different regulatory checkpoints of transcription, offering opportunities for indirect modulation of ZSCAN18 activity. For instance, Retinoic Acid, through its action on nuclear receptors, impacts the transcription of a suite of genes, including those influenced by or influencing ZSCAN18.
Epigenetic agents, particularly those influencing acetylation and methylation states of histones or DNA, are key contenders in the realm of ZSCAN18 modulation. Compounds such as VPA and SAHA, recognized for their HDAC properties, alter the acetylation landscape, subsequently influencing the transcriptional state of many genes. Similarly, agents like EPZ004777 and BIX 01294, which focus on methylation, can indirectly impact ZSCAN18 by shifting the transcriptional output of its target genes or even ZSCAN18 itself. The underlying premise here is that any chemical which has the ability to alter the transcriptional landscape in cells can, by extension, influence the activity and role of ZSCAN18 as a transcriptional regulator.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences gene transcription via its receptors. ZSCAN18, being a DNA-binding transcription factor, may have its activity or expression modulated by genes under the influence of Retinoic Acid. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. By altering the histone acetylation state, it can modulate gene transcription. ZSCAN18, as a transcription factor, can have its activity affected if the genes it regulates are influenced by these epigenetic changes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
VPA modulates gene expression by affecting histone acetylation. Given ZSCAN18's role in regulating transcription, its functionality or expression might be modulated if genes under its control are influenced by VPA-induced epigenetic changes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is another HDAC inhibitor affecting gene transcription through changes in histone acetylation. If ZSCAN18 targets genes affected by SAHA-induced acetylation, its transcriptional activity can be modulated indirectly. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can activate protein kinase C (PKC), influencing numerous cellular processes including transcriptional regulation. If PKC-mediated signaling impacts ZSCAN18's activity or the genes it targets, PMA can modulate its function. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic Acid is an inhibitor of p300 histone acetyltransferase, thereby affecting transcriptional regulation. If ZSCAN18's target genes are influenced by p300-driven acetylation, its transcriptional activity can be indirectly modulated by Anacardic Acid. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
As a DOT1L inhibitor, EPZ004777 affects gene transcription via methylation-driven changes. If ZSCAN18's activity or target genes are associated with DOT1L-controlled methylation, it can influence its function. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX 01294 inhibits G9a histone methyltransferase, thereby affecting gene transcription via histone methylation. If ZSCAN18 functions within processes influenced by G9a-governed methylation, it can indirectly modulate its activity. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $96.00 | ||
PFI-1 is a BET bromodomain inhibitor. By inhibiting the binding of bromodomains to acetylated histones, it can influence gene expression. If the genes ZSCAN18 regulates are impacted by these changes, its function can be modulated indirectly. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is an HDAC inhibitor that influences gene expression via changes in histone acetylation. If the target genes of ZSCAN18 are impacted by MS-275-induced changes, its transcriptional regulatory activity can be modulated indirectly. | ||||||