ZNHIT6 Activators
ZNHIT6 activators are a class of chemical compounds that interact with the human protein known as ZNHIT6, which is a member of the HIT (Histidine Triad) family of proteins. This family is characterized by a conserved sequence of histidine amino acids that are involved in the catalytic activity of the proteins. ZNHIT6, specifically, is a nucleotide-binding protein that has been found to play a role in various cellular processes. The activators of this protein influence its function by altering its conformation, stability, or interaction with other molecular partners, thereby affecting the activity of ZNHIT6 in a cell.
The chemical structure of ZNHIT6 activators is diverse, reflecting the different mechanisms by which they can enhance the activity of ZNHIT6. These activators are typically small molecules that can penetrate cellular membranes and reach intracellular targets. They may bind to the ZNHIT6 protein at allosteric sites, which are distinct from the active site where the natural substrates of the protein bind, or they might interact directly with the active site to promote its function. The binding of these activators can induce a conformational change in the ZNHIT6 protein structure, which can lead to an increase in its nucleotide-binding affinity or its interaction with other cellular components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is essential for the structural integrity of zinc finger proteins. Zinc sulfate can increase intracellular zinc concentration, supporting the proper folding and function of ZNHIT6. | ||||||
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $176.00 | 9 | |
A chelator that preferentially binds to iron and could indirectly increase the availability of zinc ions by altering metal homeostasis, potentially benefiting ZNHIT6's zinc-finger domains. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor, leading to hypomethylation of DNA and potentially affecting the expression of genes including those coding for nucleic acid-binding proteins like ZNHIT6. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Histone deacetylase inhibitor that can lead to a more relaxed chromatin structure and potentially increased transcription of genes, including those for nucleic acid-binding proteins. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor that enhances acetylation of histones, possibly affecting gene expression including that of nucleic acid-binding proteins. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Inhibits aldehyde dehydrogenase and can also chelate metals, which may alter metalloprotein dynamics and potentially increase zinc availability for zinc finger proteins. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Has been shown to modulate several signaling pathways and may influence the transcriptional activity of various genes, potentially including those encoding zinc finger proteins. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
An activator of the Nrf2 pathway, which regulates the expression of a battery of protective genes including some that may influence the homeostasis of metal-binding proteins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A compound from turmeric that can modulate various signaling pathways, potentially leading to upregulation of nucleic acid-binding proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol from green tea that influences multiple signaling pathways and gene expression, potentially affecting proteins involved in the nucleic acid-binding process. | ||||||