Deferasirox is a tridentate iron chelator that binds iron with high affinity in a 2:1 ratio. Although deferasirox has very low affinity for zinc and copper, there are variable decreases in the serum concentration of these trace metals after the administration of deferas.
Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),
Soluble in water (<1 mg/ml at 25° C), DMSO (75 mg/ml at 25° C), ethanol (2 mg/ml at 25° C), methanol, and ethyl acetate.
Is the deferasirox in your website a primary standard that can be used in analysis
Asked by: Iman
Thank you for your question. Please contact our technical service so we can send you a lot-specific certificate of analysis for the lot of Deferasirox (CAS 201530-41-8) that would be currently available.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06
I've dissolved it in DMSO and aliqouted it. But if I am adding it into my stock staining solution pipette tip is getting frozen due to the DMSO I assume. So how can I prevent it?
Asked by: Liss
We recommend to store the aliquoted solution in the freezer, then completely thaw it before use. Once completely thawed, the solution will be not cause the pipette tip to freeze.
Answered by: Technical Support
Date published: 2018-12-12
Any suggestions on how to dissolve in water?
Asked by: SCchem16
Thank you for your question. This chemical, Deferasirox (CAS 201530-41-8), is not very soluble in water and it is suggested to use DMSO which is soluble at 75mg/ml.
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MoritaMorita, T. et al. (PubMed 25820160) investigated the effect of iron chelation on renal cell senescence and inflammation in type I diabetic mouse kidney. Administration of Deferasirox (Exjade; ICL-670; ICL-670A; CGP-72670), a high affinity iron chelator, significantly attenuated iron accumulation in proximal tubules and the number of infiltrating F4/80-positive cells without effecting blood glucose, hematocrit or hemoglobin levels. In contrast however, Deferasirox did not influence renal cell senescence. -SCBT Publication Review
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