ZNF780A Activators
Chemical activators of ZNF780A can modulate its activity through various signaling pathways, which are crucial for its functional activation as a transcription factor. Zinc Chloride provides the essential zinc ions required for the structural integrity of zinc finger proteins like ZNF780A, which is vital for its DNA binding activity. Forskolin, by activating adenylate cyclase, leads to an elevation in cAMP levels, subsequently activating protein kinase A (PKA). PKA can phosphorylate serine and threonine residues on ZNF780A, potentially facilitating its activation. Similarly, Dibutyryl-cAMP, a cell-permeable analog of cAMP, activates PKA, which can also phosphorylate and possibly activate ZNF780A. Phorbol 12-myristate 13-acetate (PMA) is another activator that works by activating protein kinase C (PKC), which may phosphorylate ZNF780A if it possesses PKC consensus phosphorylation sites.
Ionomycin and A23187 (Calcimycin) increase intracellular calcium levels, which can trigger calcium-dependent protein kinases capable of phosphorylating ZNF780A, leading to its activation. Thapsigargin operates by inhibiting the SERCA pump, resulting in increased cytosolic calcium, which may activate kinases that phosphorylate and activate ZNF780A. Anisomycin activates MAPK/ERK kinases, which might target ZNF780A for phosphorylation. Calyculin A and Okadaic Acid, inhibitors of protein phosphatases 1 and 2A, can lead to sustained phosphorylation of ZNF780A, assuming it undergoes regular regulation by these phosphatases. Lastly, LY294002, a PI3K inhibitor, and Bisindolylmaleimide I, a PKC inhibitor, can indirectly affect the phosphorylation status of ZNF780A by altering signaling pathways and potentially activating alternative kinases that target ZNF780A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Chloride provides zinc ions which are essential for the structural integrity of zinc finger proteins like ZNF780A. Adequate zinc levels are essential for the DNA binding activity of ZNF780A, thereby directly contributing to its functional activation in the cellular context wherein it operates. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels which in turn activate PKA. PKA can phosphorylate serine and threonine residues on ZNF780A which may result in its functional activation as a transcription factor, assuming ZNF780A contains such consensus sites for PKA. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to the phosphorylation and activation of ZNF780A, assuming that ZNF780A is a substrate for PKA phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates PKC, which in turn can lead to the phosphorylation of ZNF780A if it has PKC consensus phosphorylation sites, thereby directly influencing its activation state. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium concentrations, which can activate calcium-dependent protein kinases that might phosphorylate and activate ZNF780A if it is susceptible to such regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts similarly to Ionomycin, by increasing intracellular calcium levels and thereby potentially activating calcium-sensitive kinases that could phosphorylate ZNF780A, leading to its activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the SERCA pump leading to increased cytosolic calcium, which may activate calcium-dependent kinases that could subsequently phosphorylate and activate ZNF780A. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates MAPK/ERK kinases which may phosphorylate and activate ZNF780A if it is a substrate for such kinases. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, which might result in sustained phosphorylation and therefore activation of ZNF780A if it is normally regulated by dephosphorylation through these phosphatases. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid functions similarly to Calyculin A by inhibiting protein phosphatases 1 and 2A, potentially leading to sustained phosphorylation and activation of ZNF780A. | ||||||