ZNF674 Inhibitors
ZNF674 inhibitors encompass a variety of chemical compounds that indirectly influence the expression and activity of this zinc finger protein through distinct biochemical mechanisms. For instance, specific inhibitors target the epigenetic regulation of gene expression, such as those affecting the acetylation state of histones, which can alter chromatin structure and therefore modulate the transcriptional activity of ZNF674. By changing the acetylation dynamic, these molecules potentially lead to a more condensed chromatin state, thus hindering the binding of transcription machinery to the DNA and reducing the transcription of ZNF674. Other inhibitors in this category may influence DNA methylation patterns, which are crucial for the regulation of gene expression. Altered DNA methylation can have profound effects on the transcription of genes, including those encoding zinc finger proteins, thereby reducing the levels of ZNF674 in the cell.
Another group of ZNF674 inhibitors targets signal transduction pathways and protein stability mechanisms that indirectly affect the protein's function. Inhibitors that disrupt kinase signaling pathways, such as those involved in the MAPK/ERK cascade or PI3K/Akt signaling, can lead to downstream transcriptional effects that reduce ZNF674 activity. In addition, compounds that inhibit protein degradation pathways, like the proteasome, can cause the accumulation of regulatory proteins that may suppress ZNF674 expression. Furthermore, molecules that interfere with the cell cycle, such as cyclin-dependent kinase inhibitors, could result in transcriptional repression of ZNF674 due to altered cell cycle-dependent gene regulation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This compound is a histone deacetylase inhibitor that alters the acetylation state of histones, thereby affecting chromatin structure and gene expression. By influencing gene expression, it can indirectly inhibit the transcriptional activity of ZNF674. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that reduces DNA methylation. Hypomethylated DNA can lead to altered gene expression patterns, potentially decreasing the expression of ZNF674. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
A cyclin-dependent kinase inhibitor that affects cell cycle progression. By disrupting CDK activity, it may lead to altered transcription factor dynamics and indirectly inhibit ZNF674 activity. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
An inhibitor of the transcription factor NF-κB, which is involved in the regulation of various genes, including zinc finger proteins. This can result in downstream inhibition of ZNF674 expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that prevents the degradation of proteins, including transcription factors that could regulate ZNF674. The accumulation of these factors may result in the inhibition of ZNF674 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can decrease protein synthesis. As mTOR influences the translation of a broad range of proteins, inhibition could indirectly lead to decreased levels of ZNF674. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A phosphoinositide 3-kinase inhibitor, which can disrupt signaling pathways involved in cell survival and gene expression, potentially leading to decreased expression or activity of ZNF674. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor that indirectly inhibits the MAPK/ERK pathway. Since this pathway can regulate gene expression, it may lead to altered transcriptional regulation of ZNF674. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A selective inhibitor of histone acetyltransferase p300, which is involved in chromatin remodeling and transcriptional regulation. By inhibiting p300, it could indirectly decrease ZNF674 expression. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
An inhibitor of the MDM2-p53 interaction, leading to the stabilization of p53. Increased p53 activity can lead to changes in the expression of various genes including potentially that of ZNF674. | ||||||