ZNF552 Inhibitors
Chemical inhibitors of ZNF552 can interfere with its function through various mechanisms, primarily by targeting the zinc finger domains that are crucial for the protein's DNA-binding ability. Disulfiram and clioquinol, for instance, are metal chelators that can bind to zinc ions. By sequestering zinc, these compounds prevent the proper folding and structural configuration of ZNF552's zinc finger motifs, which are essential for its interaction with DNA. Similarly, 1,10-Phenanthroline and TPEN also function as metal chelators, potentially leading to the disruption of ZNF552's zinc finger domains, thereby inhibiting the protein's DNA-binding capacity.
Additionally, other compounds such as Ebselen and Thiomersal target the cysteine residues within the protein. Ebselen, a selenium-based compound, can oxidize these residues, which might lead to a conformational change in ZNF552, preventing it from performing its regulatory functions. Thiomersal has an affinity for sulfhydryl groups and can bind to cysteine-rich regions within ZNF552, which may result in the alteration of its structure and inhibition of its activity. Cadmium chloride, on the other hand, can replace zinc in the zinc finger motifs, which could result in the improper folding of ZNF552 and lead to loss of function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate zinc ions, potentially disrupting the zinc finger domains of ZNF552, thus inhibiting its DNA-binding ability. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Clioquinol is a metal chelator which may bind to the zinc ions in the zinc finger motifs of ZNF552, inhibiting its function. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is a selenium-based compound that can oxidize cysteine residues, potentially altering the structure of zinc finger proteins like ZNF552 and inhibiting their function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Pyrithione zinc can disrupt metal homeostasis, potentially affecting the zinc finger domains of ZNF552 and inhibiting its function. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
1,10-Phenanthroline chelates metal ions and may interfere with the zinc finger domains of ZNF552, leading to inhibition of its DNA-binding capacity. | ||||||
TPEN | 16858-02-9 | sc-200131 | 100 mg | $130.00 | 10 | |
TPEN (N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine) is a zinc chelator that could sequester zinc, necessary for ZNF552's zinc finger domains, thus inhibiting its activity. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium can replace zinc in zinc finger proteins, potentially altering the structure and function of ZNF552, leading to its inhibition. | ||||||
PAC 1 | 315183-21-2 | sc-203174 sc-203174A | 10 mg 50 mg | $132.00 $536.00 | 1 | |
PAC-1 indirectly activates procaspase-3 to caspase-3, which can lead to the degradation of various proteins, potentially including ZNF552, thus inhibiting its function. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits transcription factors and could interfere with the transcriptional regulatory activities of ZNF552, leading to its inhibition. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that could lead to increased degradation of misfolded or damaged ZNF552 proteins, inhibiting its function. | ||||||