Molecular structure of PAC 1, CAS Number: 315183-21-2
PAC 1 (CAS 315183-21-2)
See product citations (1)
Application:
PAC 1 is a procaspase-activating compound
CAS Number:
315183-21-2
Purity:
>98%
Molecular Weight:
392.5
Molecular Formula:
C23H28N4O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PAC 1 is a procaspase-activating compound, which in turn produces caspase-3 (EC50 = 0.22 μM). PAC 1 also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). This compound is a proapoptotic, inducing apoptosis in both cancerous and non-cancerous cell lines. The induction of apoptosis is dependent on the concentration of procaspase-3 (IC50 values anre 0.003-1.41 and 5.02=9.98 μM, respectively).
PAC 1 (CAS 315183-21-2) References
Putt et al (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat.Chem.Biol. 2 543.Inhibitor of:
ALG1L, ARHGAP (Rho GTPase activating protein), ARL5A, C11orf59, CDSN, COG2, DDX27, DENND2D, FLASH, G-CSFR, GP2, GTPBP1, HPSE2_Hpse2, IL-27Rα, MPP10, MSE55, nRNP, PACS-1a, Pdcd-7, PRAMEF19, Programmed cell death (PDCD), PRP6, RBMY1, rhophilin, SGSM1, TMEM191B, ZGPAT, ZIP10, ZIP5, ZNF191, ZNF552, and ZNF555.Activator of:
BC030500, caspase-9, eIF4AI, MCAF2, Rab 19, reaper, and Toso.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAC 1, 10 mg | sc-203174 | 10 mg | $132.00 | |||
PAC 1, 50 mg | sc-203174A | 50 mg | $536.00 |