ZNF513 Inhibitors
Staurosporine and LY294002 act by inhibiting kinases such as PKC and PI3K, respectively, which are pivotal in regulating signaling cascades that can dictate the activity of zinc finger proteins. Triptolide, by impeding transcription factor activity, and 5-Azacytidine, through DNA methylation alteration, can modulate the transcriptional control exerted by ZNF513. MG132 and Bortezomib disrupt the proteasomal degradation pathway, thereby potentially affecting the turnover and stability of ZNF513.
U0126 and PD98059 specifically target the MEK-ERK/MAPK signaling axis, leading to changes in transcription factor activities and thereby influencing ZNF513 functions. Thalidomide engages in the modulation of proteasomal degradation of transcription factors, indirectly affecting the stability of zinc finger proteins. SB431542 hinders TGF-β signaling and thus can impact the cellular processes that control the function of ZNF513. Bromodomain inhibitors such as JQ1 and I-BET762 perturb chromatin remodeling and transcriptional elongation processes, which are crucial for gene expression. By modulating the expression of genes and the activity of transcriptional regulators, these compounds can influence the functional dynamics of ZNF513.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor; inhibits protein kinase C (PKC) which modulates transcription factors including zinc finger proteins. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that inhibits transcription factor activity, impacting zinc finger protein function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor; alters gene expression and can modify zinc finger protein binding to DNA. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor; increases levels of ubiquitinated proteins, affecting zinc finger protein degradation pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor; modulates AKT signaling which can regulate the function of zinc finger proteins. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK, leading to decreased ERK signaling; affects transcription factor function including zinc finger proteins. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Modulates degradation of transcription factors; may alter the stability of zinc finger proteins. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor; can disrupt protein turnover, including that of zinc finger proteins. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
An inhibitor of the TGF-β receptor ALK5; impacts SMAD signaling which can affect zinc finger protein functions. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor; influences transcriptional regulation and can alter the expression of genes encoding zinc finger proteins. | ||||||