ZNF508 Inhibitors
ADNP homeobox 2, often abbreviated as ADNP2, is a protein that belongs to a family of homeobox proteins known for their roles in regulating patterns of anatomical development (morphogenesis) and ensuring the proper functioning of genetic material during the life cycle of an organism. Homeobox genes encode transcription factors characterized by the presence of a 60-amino acid helix-turn-helix DNA-binding domain, known as the homeodomain, which allows them to control the expression of target genes.ADNP2 is a homologue of the Activity-Dependent Neuroprotective Protein (ADNP), which is essential for brain formation and function, playing a pivotal role in neurodevelopment and neuroprotection. The ADNP family proteins are involved in chromatin remodeling and regulation of gene expression, which are critical for cell differentiation, proliferation, and survival.
While detailed functions of ADNP2 are less characterized than its homologue ADNP, which is known to play a role in the development of the nervous system and is implicated in autism spectrum disorders and intellectual disabilities, ADNP2 has been suggested to potentially have similar regulatory functions given its structural similarities. These functions may include involvement in neural development and contributing to the transcriptional regulation of genes necessary for cell identity and fate determination.Mutations or alterations in the expression of ADNP2, as with other homeobox proteins, could have significant developmental implications and might be associated with neurological disorders. However, the specific pathways and target genes regulated by ADNP2 are not fully elucidated, necessitating additional research to uncover its exact role in development and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, potentially affecting gene expression patterns and indirectly influencing ADNP2 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase (HDAC) inhibitor, which may alter chromatin structure and gene expression, potentially impacting ADNP2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Another HDAC inhibitor, potentially affecting gene regulation and indirectly influencing ADNP2 activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A DNA methyltransferase inhibitor, which can alter gene expression and potentially impact ADNP2. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-Azacytidine, affects DNA methylation and gene expression, potentially influencing ADNP2. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A selective HDAC inhibitor, which may have implications for gene regulation involving ADNP2. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor, potentially influencing gene expression and regulatory mechanisms involving ADNP2. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
Another BET bromodomain inhibitor, which can affect transcription regulation, potentially impacting ADNP2. | ||||||
A-366 | 1527503-11-2 | sc-507495 | 10 mg | $195.00 | ||
A G9a/GLP histone methyltransferase inhibitor, potentially altering epigenetic marks and gene expression relevant to ADNP2. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
A selective EZH2/EZH1 inhibitor, potentially affecting gene expression patterns relevant to ADNP2. | ||||||