ZNF468 Inhibitors
Chemical inhibitors of ZNF468 operate through various mechanisms to disrupt the protein's function in cellular signaling and transcriptional regulation. PD168393, an irreversible inhibitor of EGFR tyrosine kinase, disrupts signaling pathways that ZNF468 may regulate transcription in response to. This leads to the functional inhibition of ZNF468's role in these pathways. Similarly, Gefitinib targets EGFR, reducing the activity of downstream cascades that ZNF468 regulates, while SU5402 inhibits FGFR, disrupting fibroblast growth factor signaling pathways that ZNF468 may regulate. Y-27632 specifically inhibits the Rho/ROCK pathway, potentially essential for cytoskeletal organization and cellular functions that ZNF468 is implicated in through transcriptional regulation, resulting in the functional inhibition of ZNF468.
Furthermore, LY294002, by inhibiting PI3K, disrupts the PI3K/AKT pathway, critical for signaling pathways involving ZNF468, leading to its functional inhibition. U0126 inhibits MEK1/2, preventing the activation of the MAPK/ERK pathway, which ZNF468 may regulate. This results in the functional inhibition of ZNF468's transcriptional regulation activity within this pathway. SB431542, an inhibitor of the TGF-beta pathway, leads to the functional inhibition of ZNF468's regulatory role. SB203580, by inhibiting p38 MAPK, functionally inhibits pathways regulated by ZNF468. SP600125 inhibits the JNK pathway, which can result in the functional inhibition of ZNF468 if it is involved in transcriptional regulation mediated by JNK signaling. PP2 disrupts signaling pathways regulated by ZNF468 by inhibiting Src family kinases, leading to the functional inhibition of ZNF468's regulatory activity. Lastly, Rapamycin inhibits mTOR, disrupting its signaling pathway crucial for processes regulated by ZNF468, and WZ4003 inhibits NUAK family kinases, affecting pathways important for ZNF468 functions, leading to its functional inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Imatinib mesylate | 220127-57-1 | sc-202180 sc-202180A | 25 mg 100 mg | $45.00 $111.00 | 61 | |
As ZNF468 is a zinc finger protein involved in transcriptional regulation, PD168393, which irreversibly inhibits EGFR tyrosine kinase, would lead to the inhibition of downstream signaling pathways that ZNF468 might be regulating transcription in response to. This would result in the functional inhibition of ZNF468's role in these pathways. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib inhibits EGFR, potentially reducing the activity of downstream signaling cascades that ZNF468 could be modulating as part of its transcriptional regulatory function, thus functionally inhibiting ZNF468. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
By inhibiting FGFR, SU5402 would disrupt fibroblast growth factor signaling pathways that ZNF468 may regulate, leading to the functional inhibition of the transcriptional activities of ZNF468. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits the Rho/ROCK pathway, which could be essential for the cytoskeletal organization and cellular functions that ZNF468 is implicated in through its transcriptional regulatory activities, resulting in its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibiting PI3K with LY294002 disrupts the PI3K/AKT pathway, which could be critical for signaling pathways that ZNF468 is involved in regulating, functionally inhibiting its activity in these pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
By inhibiting MEK1/2, U0126 prevents the activation of the MAPK/ERK pathway, which ZNF468 may regulate, functionally inhibiting the transcriptional regulation activity of ZNF468 within this pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 inhibits the TGF-beta pathway, which ZNF468 could be regulating as part of its function; this would lead to the functional inhibition of ZNF468's regulatory role in this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
As an inhibitor of p38 MAPK, SB203580 would functionally inhibit signaling pathways that ZNF468 may be involved in regulating, thus inhibiting the protein's activity in these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK pathway inhibition by SP600125 could functionally inhibit the activity of ZNF468 if it is involved in transcriptional regulation mediated by JNK signaling. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 inhibits Src family kinases, which could disrupt signaling pathways that ZNF468 regulates, leading to the functional inhibition of ZNF468's transcriptional regulatory activity. | ||||||