ZNF462 Inhibitors
Chemical inhibitors of ZNF462 function through distinct mechanisms to regulate its activity at the molecular level. PD98059 and U0126, as MEK1/2 inhibitors, prevent the activation of the MAPK/ERK pathway, which is crucial for the phosphorylation of downstream targets that influence ZNF462 activity. By inhibiting this pathway, PD98059 and U0126 ensure that the ERK-dependent transcriptional activity of ZNF462 remains unchecked. Similarly, GW5074, as a Raf-1 kinase inhibitor, also disrupts the MAPK/ERK signaling cascade at an earlier stage, leading to a similar reduction in the phosphorylation events necessary for ZNF462 to regulate gene expression effectively. On another front, SP600125 and SB203580, which inhibit JNK and p38 MAPK respectively, target other branches of the MAP kinase pathways, which could indirectly affect the modulation of ZNF462 by altering the phosphorylation status of proteins that interact with it or its target genes.
Moreover, LY294002 and Wortmannin, both PI3K inhibitors, can lead to a decrease in the PI3K/Akt pathway activity, which is known to regulate various transcription factors through post-translational modifications. In the absence of PI3K activity, the cellular environment and the state of ZNF462 could change, leading to a decline in its functional activity. In a similar vein, PP2 targets the Src family kinases, whose activity can influence the phosphorylation state and, consequently, the activity of transcription factors like ZNF462. PD168393, an EGFR tyrosine kinase inhibitor, can interfere with EGFR signaling pathways that might intersect with the regulatory mechanisms of ZNF462. Additionally, Y-27632 and SB431542, inhibitors of ROCK1 kinase and ALK5 respectively, act on other signaling routes such as cytoskeletal arrangement and TGF-beta signaling, which can have downstream effects on the regulation of ZNF462. Finally, IKK-16's inhibition of IKK touches upon the NF-κB pathway, which is upstream of many regulatory networks, potentially affecting the transcriptional control exerted by ZNF462.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK1, which is part of the MAPK/ERK pathway. ZNF462 is involved in transcription regulation that can be downstream of MAPK/ERK signaling. Inhibition of MEK1 by PD98059 would inhibit ERK phosphorylation, which can reduce ZNF462 activity in gene regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. ZNF462 function can be regulated by PI3K/Akt signaling through post-translational modifications or changes in the cellular environment that affect transcription factors. Inhibiting PI3K can disrupt these regulatory mechanisms, leading to inhibition of ZNF462's functional activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK. JNK pathway can influence the activity of transcription factors such as ZNF462 by altering the phosphorylation status of proteins that interact with ZNF462 or its target genes, thereby inhibiting ZNF462 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK. By inhibiting p38, this chemical can disrupt the phosphorylation of substrates that may interact with ZNF462, inhibiting its ability to regulate gene expression effectively. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 inhibits Src family kinases, which can phosphorylate and regulate various transcription factors. By inhibiting Src kinases, PP2 could prevent the phosphorylation and thus the functional activity of ZNF462. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, another component of the MAPK/ERK pathway. Inhibition of MEK1/2 by U0126 would prevent activation of ERK, which could be necessary for ZNF462's transcriptional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor like LY294002 and would similarly inhibit the PI3K/Akt pathway, potentially reducing post-translational modifications of ZNF462 or affecting its regulatory environment. | ||||||
PD 168393 | 194423-15-9 | sc-222138 | 1 mg | $162.00 | 4 | |
PD168393 is an irreversible inhibitor of EGFR tyrosine kinase. EGFR signaling can impact transcription factors, and its inhibition can disrupt signaling cascades that regulate ZNF462's activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK1 kinase, which is involved in cytoskeletal arrangement and possibly in the regulation of transcription factors. Inhibition of ROCK1 could lead to decreased regulation of ZNF462's transcriptional activity. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is an inhibitor of Raf-1 kinase, part of the MAPK/ERK pathway. Inhibition of Raf-1 by GW5074 would prevent downstream phosphorylation events necessary for ZNF462 function in gene regulation. | ||||||