ZNF414 Activators
ZNF414 can employ various cellular mechanisms to modulate the protein's activity, primarily through phosphorylation. Forskolin, by activating adenylate cyclase, causes an increase in cyclic AMP levels within the cell. This elevation in cAMP activates protein kinase A, which in turn can phosphorylate ZNF414, thus leading to its functional activation. Similarly, isoproterenol, which is a beta-adrenergic agonist, raises cAMP levels through the stimulation of beta-adrenoceptors, culminating in the activation of PKA and subsequent phosphorylation of ZNF414. Another cAMP analog, dibutyryl cyclic AMP, directly activates PKA, following the same route to ZNF414 activation. On a different pathway, ionomycin increases intracellular calcium concentrations, which can trigger the activation of calmodulin-dependent kinases capable of phosphorylating ZNF414. Bradykinin also raises intracellular calcium levels, potentially engaging similar calcium-sensitive kinases to affect ZNF414's phosphorylation state.
Epidermal Growth Factor, upon binding to its receptor, initiates a signaling cascade that includes the MAPK/ERK pathway, which is known to phosphorylate a range of transcription factors. Through this pathway, ZNF414 can be phosphorylated and activated. Insulin triggers its receptor, leading to the activation of the PI3K/Akt pathway, another kinase route through which ZNF414 can be phosphorylated. Phorbol 12-myristate 13-acetate activates protein kinase C, which can target transcription factors for phosphorylation, potentially including ZNF414. Lithium chloride, by inhibiting GSK-3, can alter the phosphorylation balance within the cell in a way that favors ZNF414 activation. Biochanin A, through its modulation of protein kinases, can enhance the phosphorylation and hence the activity of ZNF414. Retinoic acid, by binding to nuclear receptors, can alter gene expression and the cellular environment, which may indirectly lead to the activation of ZNF414. Lastly, sodium butyrate, as a histone deacetylase inhibitor, can change the chromatin landscape to facilitate the access of transcription factors like ZNF414 to DNA, potentially increasing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. As cAMP is a known secondary messenger, it can enhance the activity of protein kinase A (PKA), which in turn could phosphorylate ZNF414, thus leading to its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore that selectively binds to Ca2+ and increases intracellular calcium levels. Elevated Ca2+ can activate calcium-sensitive signaling pathways, potentially leading to the activation of calmodulin-dependent kinase (CaMK), which might directly or indirectly lead to the phosphorylation and activation of ZNF414. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate a variety of substrates including transcription factors. PKC-mediated phosphorylation could potentially lead to the functional activation of ZNF414 by promoting its interaction with other regulatory proteins or DNA. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that binds to beta-adrenoceptors, causing activation of adenylate cyclase and an increase in cAMP. This rise in cAMP could activate PKA, which may subsequently phosphorylate and activate ZNF414. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin engages its receptor, leading to the activation of the PI3K/Akt signaling pathway. Akt can phosphorylate a wide array of substrates, including transcription factors, and could thereby contribute to the functional activation of ZNF414 through its phosphorylation. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $75.00 $129.00 | ||
Biochanin A is a natural organic compound that has been shown to modulate the activity of various protein kinases. Through this kinase modulation, Biochanin A could enhance the phosphorylation state of ZNF414, leading to its activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to its nuclear receptors, which can modulate gene expression patterns. This can lead to changes in the cellular environment that could indirectly promote the activation of ZNF414 through altered phosphorylation states or availability of co-activators. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
db-cAMP is a cell-permeable analog of cAMP that activates PKA. The activation of PKA could result in the phosphorylation and functional activation of ZNF414. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates its receptor leading to an increase in intracellular Ca2+ levels. The elevation of Ca2+ may activate CaMK or other calcium-dependent enzymes that could contribute to the phosphorylation and subsequent activation of ZNF414. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 can lead to the stabilization and activation of various transcription factors. This inhibition might positively influence the phosphorylation state and activity of ZNF414. | ||||||