ZNF367 Activators
ZNF367, a member of the zinc finger protein family, is characterized by its role in transcriptional regulation, DNA recognition, RNA packaging, and the regulation of apoptosis and cell proliferation. Zinc finger proteins, such as ZNF367, typically contain zinc finger motifs that facilitate binding to DNA, RNA, or protein substrates, thereby influencing the transcriptional regulation of genes involved in diverse cellular processes. ZNF367, through its DNA-binding capacity, is implicated in the intricate network of gene expression regulation, modulating the activity of specific genes that are critical for cellular development, differentiation, and maintenance. The precise function of ZNF367, while not entirely elucidated, is believed to be pivotal in the context of cellular signaling pathways that govern the fate of cells, including their proliferation, apoptosis, and response to external stimuli. This positions ZNF367 as a significant molecular player in the orchestration of cellular function and integrity.
The activation of ZNF367 involves a complex interplay of molecular signals and modifications that enhance its binding affinity and transcriptional regulatory functions. Post-translational modifications, such as phosphorylation, sumoylation, or ubiquitination, can significantly impact the activity of ZNF367, altering its conformation, stability, and interactions with other biomolecules. These modifications may facilitate the localization of ZNF367 to specific genomic regions, enhancing its ability to regulate the expression of target genes. Furthermore, the activation of ZNF367 can be modulated by signaling pathways that respond to cellular stress, growth factors, or hormonal signals, which, in turn, influence the transcriptional outcomes mediated by ZNF367. Interactions with co-factors and other transcriptional regulators are also critical for the activation and function of ZNF367, enabling it to effectively participate in the transcriptional regulation networks that determine cellular phenotype and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a steroid hormone, Estradiol can activate estrogen receptors which may enhance the expression of ZNF367 if it is estrogen-responsive. This interaction could lead to an increase in ZNF367 activity by promoting its binding to DNA and influencing gene regulation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a membrane-permeable cAMP analog, activates PKA. PKA can phosphorylate transcription factors and co-regulators that may interact with ZNF367, potentially enhancing its DNA-binding ability and transcriptional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, thereby potentially affecting calcium-sensitive signaling pathways that could influence ZNF367 activity by altering its phosphorylation state or the interaction with other cofactors. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which could lead to the stabilization and activation of β-catenin. This activation might indirectly enhance ZNF367 activity by promoting the formation of transcriptional complexes that include ZNF367, if it is part of the Wnt/β-catenin signaling pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing intracellular cAMP levels and subsequently activating PKA. PKA may enhance ZNF367 activity through phosphorylation of associated factors or alteration of the chromatin structure, thereby facilitating ZNF367 binding to its target DNA sequences. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that leads to DNA demethylation. This can result in the upregulation of genes that are silenced by methylation. If ZNF367 is negatively regulated by DNA methylation, its activity could be enhanced due to the drug's action. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs). By preventing deacetylation, it leads to a more relaxed chromatin state, potentially enhancing the access of transcription factors such as ZNF367 to DNA, and thus increasing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activated PKC may phosphorylate proteins that interact with ZNF367, potentially enhancing its transcriptional activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates retinoic acid receptors that can heterodimerize with other nuclear receptors. If ZNF367 functions in concert with such receptors, its activity could be enhanced through changes in DNA binding, recruitment of co-activators, or alterations in chromatin structure. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. By inhibiting this pathway, there could be a shift in signaling balance that indirectly enhances ZNF367 activity if it is linked to this pathway or if it is regulated by proteins that are downstream of MEK. | ||||||