ZNF304 Activators
ZNF304 activators are a specialized group of chemical compounds designed to interact with the zinc finger protein 304 (ZNF304), a member of the zinc finger protein family characterized by the presence of zinc finger domains-small, functional motifs stabilized by zinc ions that facilitate protein-DNA binding. ZNF304, as with other zinc finger proteins, is typically involved in transcriptional regulation, DNA recognition, and binding, playing a role in the modulation of gene expression. Activators of ZNF304 function by enhancing the protein's ability to bind to its DNA targets, consequently influencing the transcriptional regulation of genes associated with ZNF304. These activators target specific regions of the ZNF304 protein, affecting its structural conformation, DNA-binding affinity, or interaction with other transcriptional machinery components, thereby modulating its regulatory function.
At the molecular level, ZNF304 activators are generally designed to engage with the zinc finger domains of ZNF304, or adjacent regions, to stabilize the protein in an active conformation or to increase its affinity for DNA. This can lead to a higher frequency of transcription factor-DNA interaction events, or it may enhance the specificity of ZNF304 for particular DNA sequences. The precise chemical nature of ZNF304 activators can vary significantly, ranging from small molecules to more complex organic compounds. Their development is a sophisticated process that requires an in-depth understanding of the ZNF304 structure and its interaction with DNA. Advanced techniques, including X-ray crystallography, nuclear magnetic resonance, and computational modeling, are often employed to elucidate the interaction sites and to design molecules that can effectively modulate the activity of ZNF304. The aim is to create high-affinity ligands that can specifically target ZNF304, with minimal off-target effects on other zinc finger proteins or cellular components, ensuring selective modulation of ZNF304's role in gene expression regulation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can increase intracellular cAMP, potentially enhancing the transcription of genes including ZNF304. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may interact with its receptors to modulate gene expression, potentially affecting ZNF304. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A may promote a more open chromatin state, upregulating ZNF304. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound could demethylate DNA, reversing silenced genes and potentially increasing ZNF304 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Through estrogen receptor binding, Beta-estradiol may affect the transcription of genes including ZNF304. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid could activate receptors and induce transcriptional changes, possibly upregulating ZNF304. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA may activate protein kinase C, which can influence transcriptional regulation, including that of ZNF304. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium may impact Wnt signaling and GSK-3 activity, potentially affecting ZNF304 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, which could lead to changes in gene expression profiles, including ZNF304. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
May act on the Nrf2 pathway, which can regulate the expression of detoxifying enzymes and possibly ZNF304. | ||||||