ZNF286 Activators
Forskolin enhances cellular cAMP levels, which activates protein kinase A, a kinase that can phosphorylate various transcription factors, thereby potentially modulating the expression of ZNF286. Trichostatin A and Sodium Butyrate, both histone deacetylase inhibitors, induce changes in chromatin architecture, thereby facilitating a transcriptional environment conducive to increased ZNF286 expression. Compounds like 5-Azacytidine reduce DNA methylation, which can lead to a more relaxed chromatin state around the ZNF286 gene, promoting its expression. Retinoic Acid, through its receptors, regulates gene expression patterns that may include ZNF286, altering its transcriptional activity. Lithium Chloride's inhibition of glycogen synthase kinase-3 beta (GSK-3β) influences the Wnt signaling pathway, which has broad implications for gene expression regulation, including that of ZNF286.
Epigallocatechin gallate interacts with multiple signaling pathways, potentially affecting transcription factors and co-regulators involved with ZNF286. Moreover, PD98059, a selective inhibitor of MEK1/2 in the MAPK/ERK pathway, can lead to downstream effects on transcription factor activity, which could extend to ZNF286 expression modulation. Sulforaphane, an NRF2 activator, can also alter gene expression profiles, influencing the regulation of ZNF286. PMA, activates protein kinase C, which can phosphorylate and thus modify proteins that interact with ZNF286, affecting its activity. Ionomycin, by increasing intracellular calcium, can activate calcium-sensitive signaling pathways, which may also impinge upon the regulation of ZNF286. Zinc Sulfate provides zinc ions, essential for the structural integrity of the ZNF286 protein's zinc finger domains, crucial for its DNA-binding capability and regulatory function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, resulting in increased cAMP levels, which can lead to the activation of cAMP-dependent protein kinase A (PKA). PKA, in turn, can phosphorylate transcription factors or co-regulators involved in the regulation of ZNF286. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As an inhibitor of histone deacetylase, Trichostatin A alters chromatin structure, making it more accessible for transcription factors. This modification can enhance the transcriptional activity of ZNF286 by facilitating its access to DNA. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferases, 5-Azacytidine decreases DNA methylation, which can result in the upregulation of genes. Reduced methylation may allow for increased expression or activation of ZNF286 by altering the chromatin state or the expression of regulatory factors. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts through its receptors, which can regulate gene expression. This regulation can affect the transcription or activity of ZNF286 by modifying the expression of genes that code for proteins that interact with or modify ZNF286. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), which can alter the Wnt signaling pathway. Changes in Wnt signaling may influence the regulatory network of transcription factors, including ZNF286. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol can modulate signal transduction pathways, influencing the activity of various transcription factors. These modifications in signaling pathways can affect the activity of ZNF286. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which is part of the MAPK/ERK pathway. Inhibition of MEK leads to decreased ERK phosphorylation. The MAPK/ERK pathway can regulate transcription factors and co-regulators that modulate the activity of ZNF286. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
It activates the NRF2 pathway, which can influence the transcriptional regulation of genes, including potentially those regulated by ZNF286. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate regulatory proteins that interact with ZNF286, affecting its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
It increases intracellular calcium levels, which can activate calcium-sensitive signaling pathways and potentially affect proteins that modulate the activity of ZNF286. | ||||||