ZNF233 Activators
ZNF233 can initiate a complex network of intracellular signaling pathways that converge on the phosphorylation and subsequent activation of this protein. Forskolin, by directly stimulating adenylyl cyclase, raises intracellular cAMP levels, which in turn activate protein kinase A (PKA). The activated PKA can phosphorylate ZNF233, modulating its activity. Similarly, isoproterenol, a beta-adrenergic agonist, increases cAMP in cells, leading to the activation of PKA, which then can phosphorylate ZNF233. Another cAMP analog, dibutyryl-cAMP, bypasses cell surface receptors and directly activates PKA, which again targets ZNF233 for phosphorylation.
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which has a broad range of substrates, including transcription factors that can include ZNF233. Activation of PKC by PMA thus can lead to the phosphorylation of ZNF233. Ionomycin, by increasing intracellular calcium levels, activates calmodulin-dependent kinases (CaMK), which then can also target ZNF233 for phosphorylation. Epidermal Growth Factor (EGF) operates through its receptor to activate the MAPK/ERK pathway, which can phosphorylate a variety of transcription factors, potentially including ZNF233. Insulin, through its receptor, triggers the PI3K/Akt signaling pathway, where Akt can phosphorylate a range of proteins, with ZNF233 being a possible substrate.Anisomycin activates the JNK/SAPK signaling pathway, which can lead to the phosphorylation of transcription factors, including ZNF233. Okadaic acid and calyculin A inhibit protein phosphatases 1 and 2A, causing a general increase in the phosphorylation levels of many proteins, which can result in the net activation of ZNF233. Sphingosine-1-phosphate, through its receptors, can initiate signaling cascades that may result in the activation of transcription factors, including ZNF233. Lastly, retinoic acid, by activating retinoic acid receptors, can modulate gene expression and possibly lead to the activation of ZNF233 downstream in certain signaling contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels, which can activate PKA. PKA phosphorylation can lead to the activation of ZNF233 through phosphorylation-dependent changes in its protein-protein interactions or DNA binding affinity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a wide array of target proteins. Activation of PKC may lead to subsequent phosphorylation and activation of ZNF233 as part of a signaling cascade. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calmodulin-dependent kinases (CaMK). These kinases could phosphorylate ZNF233, leading to its activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular levels of cAMP, potentially leading to the activation of PKA. PKA could then phosphorylate and activate ZNF233. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the insulin receptor and downstream PI3K/Akt signaling pathway. Akt can phosphorylate and activate various proteins, potentially including ZNF233. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a permeable analogue of cAMP that activates PKA. Activated PKA can phosphorylate ZNF233, resulting in its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the JNK/SAPK signaling pathway, which can lead to activation of transcription factors, potentially including ZNF233 through phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. Inhibition of phosphatases can result in the net activation of proteins like ZNF233 through increased phosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, similar to okadaic acid, inhibits protein phosphatases, particularly PP1 and PP2A, leading to enhanced phosphorylation and potential activation of proteins such as ZNF233. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate can activate sphingosine-1-phosphate receptors, triggering intracellular signaling cascades that could lead to the activation of transcription factors, possibly including ZNF233. | ||||||