ZNF225 Activators
ZNF225 include a variety of compounds that engage with cellular signaling pathways, leading to the functional activation of this protein. Tolfenamic acid serves as a nonsteroidal anti-inflammatory that can activate the Nrf2 pathway, which is known for its role in the transcriptional activation of antioxidant response element-dependent genes. This activation of Nrf2 can, in turn, stimulate the activity of zinc finger proteins such as ZNF225, which are involved in the cellular oxidative stress response. Similarly, sulforaphane, another activator of Nrf2, can enhance the cellular defense mechanisms that may necessitate the activation of ZNF225, as it plays a part in the cellular response to the expression of detoxifying enzymes governed by Nrf2.
Resveratrol is known to activate SIRT1, potentially deacetylating transcription factors that enhance the transcriptional activity of zinc finger proteins like ZNF225. Curcumin, with its anti-inflammatory and antioxidant properties, can activate various transcription factors that may lead to the activation of ZNF225. Retinoic acid activates retinoic acid receptors, which could interact with ZNF225, enhancing its DNA binding activity. Troglitazone, through the activation of PPARγ, might influence the promoter regions of genes regulated by ZNF225, leading to its functional activation. Forskolin and theophylline both increase cAMP levels, activating PKA, which can phosphorylate transcription factors that interact with ZNF225. EGCG can modulate signaling pathways such as NF-kB, which can influence the activity of ZNF225, while genistein can alter the phosphorylation status of proteins interacting with ZNF225. Finally, 6-Gingerol's activation of Nrf2 and capsaicin's activation of TRPV1 channels, leading to calcium influx and subsequent activation of calmodulin-dependent kinase, can both influence transcription factors that interact with ZNF225, contributing to its functional activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tolfenamic Acid | 13710-19-5 | sc-204918 sc-204918A | 5 g 25 g | $69.00 $312.00 | ||
Tolfenamic acid, a nonsteroidal anti-inflammatory drug, activates the Nrf2 pathway, leading to the transcriptional activation of antioxidant response element (ARE)-dependent genes. ZNF225 could be activated as part of the cellular response to oxidative stress mitigated by the Nrf2 pathway activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which in turn deacetylates and activates transcription factors that could enhance the transcriptional activity of zinc finger proteins such as ZNF225, particularly in stress response elements. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is an activator of Nrf2. By promoting Nrf2-mediated signaling, it can enhance the cellular defense mechanisms, potentially necessitating the activation of zinc finger proteins like ZNF225 which may be implicated in the cellular response to the detoxifying enzymes expression governed by Nrf2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates various transcription factors indirectly through its anti-inflammatory and antioxidant effects, which could lead to the activation of proteins like ZNF225 that may be involved in these signaling cascades by promoting the binding of these transcription factors to DNA elements where ZNF225 might exert its function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates retinoic acid receptors (RARs) which can heterodimerize with other transcription factors, potentially enhancing the DNA binding and transcriptional activation of downstream target genes including those where ZNF225 exerts regulatory functions. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone activates PPARγ, which may interact with the promoter regions of genes that are regulated by zinc finger proteins such as ZNF225, leading to a conformational change and functional activation of these proteins in the context of gene regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels and activating PKA. PKA can phosphorylate transcription factors, potentially leading to the activation of zinc finger proteins like ZNF225, as part of the cellular response to hormone signaling. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline, by increasing intracellular cAMP levels, can activate PKA, which may phosphorylate and activate transcription factors that interact with zinc finger proteins like ZNF225, modulating their DNA binding activity and leading to their functional activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can modulate various signaling pathways including NF-kB, which can influence the activity of zinc finger proteins. By enhancing the transactivation potential of NF-kB, EGCG might promote the functional activation of ZNF225 within the context of immune response regulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can also modulate cell signaling pathways. By altering the phosphorylation status of proteins that interact with zinc finger proteins such as ZNF225, genistein might lead to the functional activation of ZNF225 through changes in transcription factor activities. | ||||||