Gingerol (CAS 23513-14-6)

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Alternate Names: 6-Gingerol

Application: Gingerol is an apoptosis inducing, anti-oxidative and anti-inflammatory agent

CAS Number: 23513-14-6

Purity: ≥98%

Molecular Weight: 294.38

Molecular Formula: C₁₇H₂₆O₄

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Gingerol, a phenolic substance and a potent cardiotonic agent isolated from the rhizome of ginger, has been shown to stimulate the Ca²⁺-pumping activity of sarcoplasmic reticulum (SR) of rabbits in a concentration-dependent manner. It was noted that Gingerol specifically activated SERCA (Ca²⁺-ATPase of cardiac and skeletal SR). Additional research has shown Gingerol to inhibit platelet aggregation via suppression of thromboxane production. Gingerol blocked ATP release from platelets induced by adrenaline and adenosine 5-diphosphate and prevented secondary aggregation. It has been demonstrated that Gingerol contains antioxidant and antiinflammatory characteristics and could significantly inhibit 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis in mice. Furthermore, Gingerol has been noted as an agonist of the capsaicin-activated VR1 (vanilloid receptor) and in leukemia cell studies it has been shown to have apoptotic properties.

References

1. Kobayashi, M., et al. 1987. Biochim. Biophys. Acta. 903: 96-102. PMID: 2443170
2. Guh, J.H., et al. 1995. J. Pharm. Pharmacol. 47: 329-332. PMID: 7791032
3. Lee, E. and Surh,Y.J. 1998. Cancer Lett. 134: 163-168. PMID: 10025876
4. Dedov, V.N., et al. 2002. Br. J. Pharmacol. 137: 793-798. PMID: 12411409

Appearance :

Oil

Physical State :

Solid

Derived From :

<i>Zingiber Officinale Rosc</i>

Solubility :

Soluble in ethanol, benzene, ether, chloroform, methanol (1 mg/ml), and DMSO. Insoluble in water.

Storage :

Store at -20° C

Melting Point :

20-25° C

Boiling Point :

~453.0° C at 760 mmHg (Predicted)

Density :

~1.1 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.52

IC50 :

Ca2+-ATPase : EC₅₀50 = 4 µM ( cardiac sarcoplasmic reticulum)

Ki Data :

Serotonin 1a (5-HT1a) receptor: K_i= >100 µM (human)

pK Values :

pK_a: 10.02

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

HE0757000

PubChem CID :

442793

Merck Index :

14: 4424

MDL Number :

MFCD00210507

SMILES :

CCCCC[[email protected]@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O

Download SDS (MSDS)

Certificate of Analysis

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