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Tolfenamic Acid (CAS 13710-19-5)

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Application:
Tolfenamic Acid is a non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes
CAS Number:
13710-19-5
Purity:
≥98%
Molecular Weight:
261.70
Molecular Formula:
C14H12ClNO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tolfenamic acid is a nonsteroidal anti-inflammatory compound that functions as an inhibitor of cyclooxygenase (COX) enzymes. It targets the COX-1 and COX-2 isoforms, thereby reducing the production of prostaglandins from arachidonic acid. This inhibition of prostaglandin synthesis leads to a decrease in inflammation, pain, and fever. Tolfenamic acid achieves this by reversibly binding to the active site of the COX enzymes, preventing the conversion of arachidonic acid to prostaglandin H2. As a result, it modulates the inflammatory response and provides a means to study the role of prostaglandins in various experimental models. Tolfenamic acid may exhibit antiproliferative effects in certain cancer cell lines, suggesting a potential role in cancer studies. Its ability to inhibit COX enzymes makes it useful for investigating the molecular pathways involved in inflammation and cancer progression.


Tolfenamic Acid (CAS 13710-19-5) References

  1. Biocompatible Cationic Lipoamino Acids as Counterions for Oral Administration of API-Ionic Liquids.  |  Lai, A., et al. 2022. Pharm Res. 39: 2405-2419. PMID: 35661084
  2. Tolfenamic acid inhibits ROS-generating oxidase Nox1-regulated p53 activity in intrastriatal injection of malonic acid rats.  |  Yang, X., et al. 2022. J Physiol Sci. 72: 15. PMID: 35850611
  3. Antimicrobial Activity of Auranofin, Cannabidivarin, and Tolfenamic Acid against Multidrug-Resistant Neisseria gonorrhoeae.  |  Yang, F., et al. 2022. Microbiol Spectr. 10: e0395222. PMID: 36350125
  4. Do Pharmaceuticals in the Environment Pose a Risk to Wildlife?  |  Bean, TG., et al. 2022. Environ Toxicol Chem.. PMID: 36398854
  5. How painful are cats after neutering - a field study using multimodal analgesia with intraperitoneal ropivacaine in a -neuter-return program in feral cats.  |  Heitzmann, V., et al. 2022. Schweiz Arch Tierheilkd. 164: 841-850. PMID: 36454013
  6. Dual-analgesic loaded UHMWPE exhibits synergistic antibacterial effects against Staphylococci.  |  Gil, D., et al. 2023. J Biomed Mater Res B Appl Biomater. 111: 912-922. PMID: 36462210
  7. Effect of nonsteroidal anti-inflammatory drugs on the inflammatory response of bovine endometrial epithelial cells in vitro.  |  Crookenden, MA., et al. 2023. J Dairy Sci. 106: 2651-2666. PMID: 36653292
  8. Regularities of Encapsulation of Tolfenamic Acid and Some Other Non-Steroidal Anti-Inflammatory Drugs in Metal-Organic Framework Based on γ-Cyclodextrin.  |  Delyagina, E., et al. 2022. Pharmaceutics. 15: PMID: 36678700
  9. Metformin-NSAIDs Molecular Salts: A Path towards Enhanced Oral Bioavailability and Stability.  |  Acebedo-Martínez, FJ., et al. 2023. Pharmaceutics. 15: PMID: 36839770
  10. Development of a detection method for 10 non-steroidal anti-inflammatory drugs residues in four swine tissues by ultra-performance liquid chromatography with tandem mass spectrometry.  |  Sun, Z., et al. 2023. J Chromatogr B Analyt Technol Biomed Life Sci. 1223: 123722. PMID: 37099884
  11. Administration of ketoprofen in postpartum sows to control the incidence of post-parturient disorders and improve piglet survival rate.  |  Jeeraphokhakul, S., et al. 2023. Anim Biosci. 36: 1293-1303. PMID: 37170523
  12. Analysis of Tolfenamic Acid Using a Simple, Rapid, and Stability-Indicating Validated HPLC Method.  |  Kazi, SH., et al. 2023. Antiinflamm Antiallergy Agents Med Chem.. PMID: 37291774
  13. Conformational State of Fenamates at the Membrane Interface: A MAS NOESY Study.  |  Khodov, IA., et al. 2023. Membranes (Basel). 13: PMID: 37367811

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tolfenamic Acid, 5 g

sc-204918
5 g
$69.00

Tolfenamic Acid, 25 g

sc-204918A
25 g
$312.00

Nuestra empresa, SUPER'S DIANA, es un laboratorio fabricante de medicamentos veterinarios y está interesado en el ácido tolfenámico, desearíamos saber el fabricante de este API y su precio. Gracias y saludos.

Asked by: Mercè ESPINOSA
Santa Cruz Biotechnology, Inc. no es una empresa con certificado ISO. Nuestros productos son para uso exclusivo en investigación y, por lo tanto, no están regulados de la misma manera que los reactivos para uso clínico o de diagnóstico. No practicamos GMP (Buenas prácticas de fabricación) pues nuestros productos son para uso exclusivo en investigación en ningún caso se recomiendan para diagnóstico o producción. No ofrecemos documentos DMF porque nuestros productos químicos son para uso exclusivo en investigación.
Answered by: Technical Support Europe
Date published: 2017-03-08
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Rated 5 out of 5 by from Shao et alShao et al. (PubMed ID 25593642) found that the NSAID, toifenamic acid, suppressed inflammation via obstruction of the NF-kB pathway in TNF-alpha stimulated human normal and caner cells. -SCBT Publication Review
Date published: 2015-01-30
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Tolfenamic Acid is rated 5.0 out of 5 by 1.
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