ZNF219 Activators
ZNF219 activators encompass a diverse array of chemical compounds that enhance the functional activity of the transcription factor ZNF219 through various indirect biochemical pathways. Forskolin, by raising intracellular cAMP levels, activates PKA, which can lead to the phosphorylation of proteins that interact with ZNF219, hence potentially augmenting ZNF219's DNA binding capability. Similarly, the calcium ionophore Ionomycin can elevate intracellular calcium levels, influencing calcium-dependent signaling pathways that may modify ZNF219's activity. Phorbol 12-myristate 13-acetate (PMA) functions to activate PKC, which is implicated in a myriad of signaling pathways, potentially leading to the post-translational modifications of ZNF219 that enhance its activity. DNA methyltransferase inhibition by 5-Azacytidine, and the increase in histone acetylation induced by Trichostatin A and Sodium Butyrate, could lead to epigenetic changes that foster ZNF219's expression and its transcriptional engagement.
In addition to these epigenetic modifiers, retinoic acid may also upregulate ZNF219 by affecting the transcriptional machinery, while the cAMP analog db-cAMP and the green teacomponent EGCG may indirectly modulate the activity of ZNF219 by influencing the phosphorylation of related proteins. Curcumin, with its broad effects on signaling molecules and transcription factors, might also contribute to the enhanced activity of ZNF219 through complex pathway interactions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin indirectly enhances the activity of ZNF219 by increasing cAMP levels, which in turn activates PKA. PKA then can phosphorylate proteins that interact with ZNF219, potentially increasing its DNA binding activity and function in transcription regulation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels and potentially affecting calcium-dependent signaling pathways that may indirectly activate ZNF219 by altering its conformation or interactions with other proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA functions as a potent activator of protein kinase C (PKC), which is involved in various signaling cascades that can indirectly lead to the activation of ZNF219 through phosphorylation or other post-translational modifications. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can cause hypomethylation of gene promoters, potentially leading to the increased expression of ZNF219 by altering the epigenetic state of its promoter region. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an inhibitor of histone deacetylases (HDACs), which may increase the acetylation of histones around the ZNF219 gene, enhancing the accessibility of the transcriptional machinery and indirectly increasing ZNF219 expression and function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences gene expression through its receptor, which can activate transcription factors and co-activators that may enhance the transcriptional activity of ZNF219 by facilitating its interaction with DNA. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
db-cAMP, a cAMP analog, can mimic cAMP's effect in activating PKA, which may lead to phosphorylation events that enhance the activity of ZNF219 in its role as a transcription factor. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit several protein kinases, which can reduce competitive signaling pathways and indirectly increase the functional activity of ZNF219 by altering the phosphorylation state of interacting proteins. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate acts as an HDAC inhibitor, which can enhance histone acetylation and potentially increase ZNF219 expression by improving the transcriptional accessibility of its gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin interacts with various signaling molecules and transcription factors, which might indirectly enhance ZNF219 activity through modulation of these pathways and transcriptional co-regulation. | ||||||