ZNF197 Inhibitors

Zinc finger protein 197 (ZNF197) is a member of the zinc finger protein family characterized by the presence of zinc finger domains, which are small structural motifs that stabilize protein folds through coordination with a zinc ion. These domains enable ZNF197 to bind DNA, RNA, or other proteins, conferring on it the role of a transcription factor or a mediator in various protein interactions. The '197' denotes its specific identifier within the vast zinc finger protein family, which encompasses hundreds of proteins with diverse functions.The characteristic feature of ZNF197, like other zinc finger proteins, is the ability to interact with DNA in a sequence-specific manner. This interaction typically occurs in the major groove of DNA, where the protein can either promote or repress the transcription of target genes. Through this regulatory role, ZNF197 influences a variety of cellular processes, including development, differentiation, and apoptosis.

The structure of ZNF197 typically includes several zinc finger domains, each consisting of about 30 amino acids that fold around a single zinc ion. These domains are often described as "fingers" that reach into the DNA structure to make contact at specific points, allowing ZNF197 to exert precise control over gene expression.ZNF197 is encoded by the ZNF197 gene located in the human genome. Changes in the expression levels or mutations in the ZNF197 gene can have significant biological consequences and are associated with various diseases, including cancers and developmental disorders. Understanding the specific genes regulated by ZNF197 and its interaction with other proteins can provide insight into its role in these disease processes.