ZNF143 Inhibitors
ZNF143 inhibitors belong to a specific chemical class designed to modulate the activity of the zinc finger protein 143 (ZNF143). Zinc finger proteins, characterized by their distinct zinc ion-binding motifs, play crucial roles in gene expression regulation by binding to specific DNA sequences. ZNF143, in particular, functions as a transcription factor, participating in the control of various cellular processes, including cell cycle progression and DNA replication. Inhibitors targeting ZNF143 are designed to interfere with its normal binding to DNA, thereby influencing the downstream gene expression programs it regulates.
The development of ZNF143 inhibitors is rooted in the recognition of the protein's importance in cellular functions and its implication in various diseases. Researchers have focused on designing small molecules that selectively target the binding interfaces of ZNF143, aiming to disrupt its interactions with DNA. Structural studies and molecular modeling have played a pivotal role in the rational design of these inhibitors, providing insights into the specific interactions between ZNF143 and its target DNA sequences. By perturbing these interactions, ZNF143 inhibitors have the potential to modulate gene expression patterns associated with specific cellular processes, paving the way for exploring their impact on cellular pathways in various biological contexts.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Inhibits DNA methyltransferases, leading to reduced DNA methylation and potentially affecting ZNF143 binding affinity to DNA. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase inhibitor, altering chromatin structure and thus affecting the transcriptional activity of ZNF143. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can increase the levels of ubiquitinated proteins, potentially affecting ZNF143 stability. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to intercalate into DNA, which may hinder DNA binding proteins like ZNF143 from accessing their target sites. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Has been shown to affect DNA methylation and histone modification, potentially altering ZNF143 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that can lead to a more relaxed chromatin state, influencing ZNF143-mediated transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
DNA-binding antitumor antibiotic that may interfere with ZNF143 binding to DNA by competition. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor, affecting the reading of acetylated histones and potentially altering ZNF143-mediated transcription. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
Small molecule inhibitor of the CBP/p300 bromodomains, indirectly affecting transcription factors like ZNF143. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Isoflavone that can modulate several signaling pathways and potentially influence ZNF143 activity. | ||||||