ZNF114 Activators
Zinc Pyrithione can lead to enhanced activation of its associated transcription factors through a variety of molecular pathways. Zinc Pyrithione itself can bind directly to the zinc finger domains of transcription factors, stabilizing their configuration and improving their DNA-binding capability. Similarly, Forskolin increases intracellular cAMP levels, which in turn activates protein kinase A (PKA). PKA is known to phosphorylate a host of transcription factors and coactivators, which could enhance the DNA binding and transcriptional activity of Zinc Pyrithione-associated proteins. Phorbol 12-myristate 13-acetate (PMA) functions by activating protein kinase C (PKC), which phosphorylates regulatory proteins that can interact with Zinc Pyrithione, thereby augmenting its DNA-binding efficiency and gene regulation potency.
In the same vein, Ionomycin works by increasing intracellular calcium levels, which activates calmodulin-dependent kinases capable of phosphorylating proteins that may associate with Zinc Pyrithione. This process can potentially lead to more robust activation of Zinc Pyrithione's transcriptional functions. Epidermal Growth Factor (EGF) stimulates the EGF receptor pathway culminating in the activation of MAPK/ERK signaling, which can phosphorylate transcription factors involved with Zinc Pyrithione, thus enhancing its regulatory activity. Isoproterenol, through its agonist action on beta-adrenergic receptors, also raises cAMP levels and activates PKA, which could lead to the phosphorylation of Zinc Pyrithione-associated proteins. Retinoic Acid can modulate gene expression and cell differentiation, affecting the activity of transcription factors that regulate Zinc Pyrithione, while Dibutyryl-cAMP, a cAMP analog, activates PKA that can phosphorylate coactivators of Zinc Pyrithione. Sodium Butyrate, a histone deacetylase inhibitor, relaxes chromatin structure, potentially improving Zinc Pyrithione's access to DNA. Lithium Chloride's inhibition of GSK-3 could stabilize and activate transcriptional cofactors affecting Zinc Pyrithione activity. Additionally, Trichostatin A, another histone deacetylase inhibitor, and 5-Azacytidine, which reduces DNA methylation, can both modify chromatin to facilitate the transcriptional activity of Zinc Pyrithione.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione can activate ZNF114 by binding to and stabilizing the zinc finger domains of the protein, which often require zinc ions for proper configuration and function, thereby enhancing its DNA-binding capability, crucial for its role as a transcription factor. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate regulatory proteins that interact with ZNF114, leading to an enhanced ability of ZNF114 to bind DNA and modulate gene expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as an ionophore for calcium. Elevated intracellular calcium levels can activate calmodulin-dependent kinase, which may phosphorylate proteins associated with ZNF114, leading to enhanced activation of ZNF114's DNA binding and regulatory functions. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol acts as an agonist of beta-adrenergic receptors, which increases cAMP and activates PKA. PKA activation can lead to phosphorylation of proteins that may interact with ZNF114, promoting the activation of ZNF114's function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences cell differentiation and gene expression. It can modulate the activity of retinoic acid receptors, which may heterodimerize with other transcription factors or influence cofactors that regulate ZNF114, leading to its activation in gene regulatory processes. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. PKA can then phosphorylate proteins within the transcriptional machinery or cofactors that interact with ZNF114, leading to enhanced activation of ZNF114's transcriptional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a histone deacetylase inhibitor, which leads to a more relaxed chromatin structure and can facilitate the access of transcription factors like ZNF114 to DNA, thereby potentially enhancing ZNF114's ability to activate gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, which can lead to the stabilization and activation of β-catenin. Activated β-catenin can enter the nucleus and activate transcription factors and co-factors that may enhance the DNA binding and activation potency of ZNF114. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is another histone deacetylase inhibitor that promotes a more open chromatin state, potentially facilitating ZNF114 access to DNA and enhancing its capacity to activate transcription of its target genes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to reduced methylation of DNA and histones, thereby affecting chromatin structure and gene expression. It could facilitate ZNF114's access to its target sites, enhancing its transcriptional activation potential. | ||||||