ZMAT2 Inhibitors
ZMAT1 inhibitors comprise a selection of chemical compounds that interfere with the protein's functionality by targeting the specific pathways and processes essential for its activity. The molecular architecture of ZMAT1 relies heavily on the integrity of its zinc finger domain, a structural motif that coordinates zinc ions to stabilize its three-dimensional form. Compounds such as heavy metals can displace zinc in these domains, leading to direct conformational changes that hamper ZMAT1's ability to bind to its target molecules, thereby inhibiting its function. Additionally, the regulation of protein folding is crucial, and substances that impede the protein quality control mechanisms, like proteasome inhibitors, result in an accumulation of misfolded proteins, indirectly affecting ZMAT1's stability and activity by overwhelming the cellular systems responsible for maintaining protein function.
Furthermore, ZMAT1's activity is intricately linked to various cellular signaling pathways, such as the PI3K/AKT and MAPK pathways, and inhibitors of these can alter the molecular chaperones and transcriptional regulatory networks ZMAT1 depends on. For instance, PI3K inhibitors can disrupt the signaling cascade that influences the chaperones associated with ZMAT1 folding and stability. Similarly, compounds that inhibit the MAPK pathway may affect the phosphorylation status of transcription factors and cofactors that interact with ZMAT1, potentially altering its ability to regulate gene expression. By interfering with these pathways, the inhibitors can diminish ZMAT1's role in orchestrating the transcriptional response to cellular stimuli, which may have implications for various biological processes including cell growth, apoptosis, and the response to oxidative stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
This compound inhibits the activity of aldehyde dehydrogenase (ALDH) by chelating with copper in the ALDH enzyme, which could indirectly lead to the inhibition of ZMAT1, as ZMAT1 requires proper protein folding that is potentially influenced by aldehyde metabolism. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
As an inhibitor of autophagy by preventing endosome-lysosome fusion, this compound may lead to the accumulation of misfolded proteins, indirectly inhibiting ZMAT1 by disrupting its normal zinc finger domain folding process which is crucial for its function. | ||||||
6-Aminonicotinamide | 329-89-5 | sc-278446 sc-278446A | 1 g 5 g | $153.00 $390.00 | 3 | |
A nicotinamide adenine dinucleotide (NAD+) antagonist that inhibits the pentose phosphate pathway, potentially causing a decrease in nucleotide synthesis, which could indirectly inhibit ZMAT1 by limiting available resources for zinc finger domain maintenance and activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that could lead to an increase in misfolded or damaged proteins, potentially indirectly inhibiting ZMAT1 by overwhelming the protein quality control system, which is essential for ZMAT1's function. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
As a heavy metal, cadmium can displace zinc in zinc finger proteins, potentially resulting in the functional inhibition of ZMAT1 by altering its structural conformation and binding capabilities. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Binds to FKBP12, forming a complex that inhibits calcineurin. This inhibition could indirectly affect ZMAT1's function by altering signaling pathways that rely on calcium signaling, which may impact ZMAT1's zinc finger domain regulatory functions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor that can cause hyperacetylation of histones, potentially leading to altered gene expression patterns that indirectly inhibit ZMAT1 by affecting the transcriptional regulatory networks in which ZMAT1 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that could indirectly inhibit ZMAT1 by altering the PI3K/AKT signaling pathway, which may influence the molecular chaperones associated with ZMAT1's folding and stability. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate transcription factors such as NF-κB. This could indirectly inhibit ZMAT1 by altering the expression of genes that interact or regulate ZMAT1's function within the nucleus. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that could indirectly inhibit ZMAT1 by causing a buildup of ubiquitinated proteins, potentially disrupting the ubiquitin-proteasome pathway which ZMAT1 may be a part of, thus affecting its function. | ||||||