ZHX1 Inhibitors
Chemical inhibitors of ZHX1 utilize various strategies to modulate its activity by targeting the NF-κB pathway, with which ZHX1 interacts to influence gene transcription. Triptolide acts by inhibiting the NF-κB pathway, thus limiting the transcriptional activity that ZHX1 would enhance. MG132, a proteasome inhibitor, prevents the degradation of IκB, thereby impeding NF-κB activation that ZHX1 may otherwise facilitate. SN50 applies a different mechanism, inhibiting the nuclear translocation of NF-κB and thereby indirectly preventing ZHX1 from exerting its effects on gene transcription regulation. Another inhibitor, BAY 11-7082, irreversibly inhibits IκBα phosphorylation, thwarting NF-κB activation and subsequently the transcriptional enhancement by ZHX1.
Curcumin operates by blocking the phosphorylation and degradation of IκBα, which can functionally inhibit ZHX1 by reducing the transcriptional activity it would promote. PS-1145, similar to the quinazoline derivative, inhibits IKK, a kinase crucial for NF-κB activation, hence stifling the transcriptional activity of ZHX1. Parthenolide also inhibits the NF-κB pathway by preventing IκBα degradation, which in turn inhibits ZHX1's function. IMD-0354 specifically targets IKKβ, leading to the inhibition of NF-κB signaling and the associated transcriptional regulatory effects of ZHX1. JSH-23 impedes the nuclear translocation of NF-κB p65 subunit, disrupting the pathway's activation and the consequent regulation of transcription by ZHX1. Helenalin and sulforaphane represent additional inhibitors; helenalin binds directly to the p65 subunit to inhibit NF-κB's transcriptional activity, while sulforaphane promotes IκBα stabilization and inhibits IKK, both leading to the functional inhibition of ZHX1's role in transcriptional modulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the NF-κB pathway, which ZHX1 can modulate through its interaction with NF-κB p65 subunit. By inhibiting NF-κB, triptolide can reduce the transcriptional activity that ZHX1 would normally enhance, thereby functionally inhibiting ZHX1's activity in cells. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of IκB, thus inhibiting the activation of the NF-κB pathway. Since ZHX1 interacts with the NF-κB complex, the inhibition of this pathway can suppress the potential enhancement of transcriptional activity by ZHX1, leading to its functional inhibition. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 irreversibly inhibits IκBα phosphorylation, which blocks NF-κB activation and thus its pathway. Since ZHX1's transcriptional activity can be linked to the NF-κB pathway, the use of BAY 11-7082 can lead to a functional inhibition of ZHX1 by preventing NF-κB-mediated transcriptional enhancement. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to inhibit the NF-κB pathway by blocking the phosphorylation and degradation of IκBα. This action can functionally inhibit ZHX1 by reducing the transcriptional activity that ZHX1 would enhance through NF-κB pathway modulation. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits the NF-κB pathway by preventing IκBα degradation. By blocking this pathway, parthenolide can functionally inhibit ZHX1 by reducing its ability to enhance transcriptional activity through NF-κB. | ||||||
IMD 0354 | 978-62-1 | sc-203084 | 5 mg | $199.00 | 3 | |
IMD-0354 specifically inhibits IKKβ, leading to the inhibition of the NF-κB signaling pathway. As ZHX1 can interact with NF-κB, blocking this pathway with IMD-0354 can functionally inhibit the transcriptional regulatory effects of ZHX1. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
JSH-23 inhibits the nuclear translocation of NF-κB p65 subunit, thereby blocking NF-κB pathway activation. Inhibition of this pathway can result in the functional inhibition of ZHX1 by preventing the enhancement of transcriptional activity that ZHX1 is involved in through its association with NF-κB. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane inhibits the NF-κB pathway by promoting IκBα stabilization and inhibiting IKK. This leads to the functional inhibition of ZHX1 since it can no longer facilitate the transcriptional enhancement typically mediated by the NF-κB pathway, which is part of ZHX1's functional repertoire. | ||||||