Chemical activators of zinc finger protein 773 can engage in a variety of biochemical interactions to ensure the protein's functional activation. Zinc Pyrithione can elevate intracellular zinc levels, which is crucial for the maintenance of zinc finger domains in zinc finger protein 773, ensuring proper DNA binding and function. Forskolin, by increasing intracellular cAMP, activates protein kinase A (PKA), which can phosphorylate specific substrates that play a role in the activation of zinc finger protein 773. Similarly, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C, which can also target proteins that regulate the activity of zinc finger protein 773, leading to its activation. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent kinases which may phosphorylate and thus activate zinc finger protein 773.
Furthermore, 5-Azacytidine, by integrating into nucleic acids, can disrupt methylation patterns that might otherwise suppress the activity of zinc finger protein 773, thereby facilitating its activation. Histone deacetylase inhibitors such as Trichostatin A and Sodium Butyrate can promote a more open chromatin conformation, enhancing the DNA binding capability of zinc finger protein 773 and its subsequent activation. Valproic Acid operates in a similar manner, providing a chromatin context that supports the activation of zinc finger protein 773. Retinoic Acid, through its influence on gene transcription, can lead to post-translational modifications that activate zinc finger protein 773. Dibutyryl-cAMP, a cAMP analogue, can directly activate PKA, thus promoting the phosphorylation and activation of zinc finger protein 773. Epigallocatechin Gallate and Curcumin can modulate signaling pathways and inhibit phosphatases, which results in an increased phosphorylation state that is conducive to the activation of zinc finger protein 773. Each of these chemicals ensures the activation of zinc finger protein 773 through distinct but converging pathways that potentiate its DNA binding and regulatory functions within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Activates zinc finger protein 773 by increasing intracellular zinc concentration, which is necessary for the structural integrity of zinc finger domains allowing proper DNA binding. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C which can phosphorylate and change the function of proteins that regulate zinc finger protein 773, resulting in its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium, thus activating calcium-dependent kinases that could phosphorylate and activate zinc finger protein 773. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Incorporates into RNA and DNA and can disrupt cellular methylation patterns, which may remove inhibitory methylation marks on zinc finger protein 773, leading to its activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylases, causing a more open chromatin structure around zinc finger protein 773, potentially facilitating its DNA binding and activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Acts as a histone deacetylase inhibitor, promoting a relaxed chromatin state for more accessible DNA binding sites for zinc finger protein 773, leading to activation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Inhibits histone deacetylase, which can lead to an open chromatin conformation and subsequent activation of zinc finger protein 773 by facilitating its access to DNA. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences gene transcription through its receptors which may lead to post-translational modifications of zinc finger protein 773, resulting in its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Mimics cAMP and activates PKA, which can then phosphorylate and activate zinc finger protein 773. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Affects various signaling pathways and might inhibit phosphatases, leading to increased phosphorylation and activation of zinc finger protein 773. | ||||||