ZFP141 Inhibitors
Zfp141, a zinc finger protein, is implicated in transcriptional regulation through its DNA-binding activities and involvement in RNA polymerase II cis-regulatory region binding. Predicted to enable DNA-binding transcription factor activity, Zfp141 plays a key role in modulating gene expression. The protein is primarily active in the nucleus, orchestrating the intricate control of RNA polymerase II-mediated transcription.
Inhibition of Zfp141 can be achieved through various chemical entities targeting key cellular processes. Direct inhibitors, such as Actinomycin D and Triptolide, impact RNA polymerase II activity, directly interfering with Zfp141's DNA-binding functions. Indirect inhibitors, like Flavopiridol and Trichostatin A, influence Zfp141 by disrupting cellular pathways related to transcription and chromatin structure. The specific biochemical mechanisms through which each inhibitor acts provide a nuanced understanding of Zfp141 inhibition, laying the groundwork for further exploration of targeted modulation in the context of transcriptional regulation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D, a transcription inhibitor, directly interferes with RNA polymerase II activity. By impeding the progression of RNA polymerase II, it indirectly inhibits Zfp141's DNA-binding and regulatory functions. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits RNA polymerase II-mediated transcription, directly impacting Zfp141's DNA-binding activity. This inhibition occurs through interference with the transcriptional machinery, affecting Zfp141 function. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol, a CDK inhibitor, directly disrupts the cell cycle and RNA polymerase II activity, indirectly inhibiting Zfp141. The inhibition of CDKs influences Zfp141's transcriptional regulation functions. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-Amanitin, an RNA polymerase II inhibitor, directly hinders RNA polymerase II activity, affecting Zfp141's transcriptional functions. The disruption of RNA polymerase II directly inhibits Zfp141. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil, a thymidylate synthase inhibitor, indirectly influences Zfp141 by disrupting DNA synthesis. The inhibition of thymidylate synthase impacts Zfp141's ability to bind to cis-regulatory regions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, an HDAC inhibitor, directly modulates chromatin structure, affecting Zfp141's access to cis-regulatory regions. The inhibition of HDACs indirectly impacts Zfp141's DNA-binding activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, indirectly affects Zfp141 by altering DNA topology. The inhibition of topoisomerase II influences Zfp141's DNA-binding and transcriptional regulatory functions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin, a topoisomerase I inhibitor, directly impacts DNA dynamics, indirectly inhibiting Zfp141. The disruption of topoisomerase I activity influences Zfp141's DNA-binding and regulatory functions. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin, a DNA cross-linker, indirectly affects Zfp141 by altering DNA structure. The modification of DNA structure impacts Zfp141's ability to bind to cis-regulatory regions, influencing its regulatory functions. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB, an RNA synthesis inhibitor, directly disrupts RNA polymerase II activity, impacting Zfp141's DNA-binding and regulatory functions. The inhibition of RNA synthesis affects Zfp141 function. | ||||||