ZFP141 Activators
Zfp141, a zinc finger protein, plays a crucial role in transcriptional regulation by RNA polymerase II, exhibiting DNA-binding transcription factor activity. Predominantly localized in the nucleus, Zfp141 is involved in the intricate control of gene expression through its specific binding to cis-regulatory regions. The protein is predicted to orchestrate the regulation of transcription, showcasing its significance in cellular processes.
The activation of Zfp141 involves intricate epigenetic modifications and chromatin dynamics. Several chemicals, such as Azacitidine and 5-Azacytidine, act as indirect activators by demethylating DNA, promoting Zfp141's binding to cis-regulatory regions and enhancing RNA polymerase II-specific DNA binding. HDAC inhibitors like Trichostatin A and SAHA influence histone acetylation, altering chromatin structure to facilitate Zfp141-mediated transcriptional regulation. Natural compounds like Curcumin and Betulinic Acid exert their effects through anti-inflammatory mechanisms, modulating chromatin accessibility for Zfp141 binding. In summary, Zfp141 emerges as a key player in the regulation of gene expression, with its activation intricately tied to epigenetic modifications and chromatin dynamics. Understanding the mechanisms underlying Zfp141 activation provides valuable insights into the complex landscape of transcriptional control in various cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor impacting DNA methylation. Potential indirect activator of Zfp141 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. Azacitidine's role involves epigenetic modifications that enhance Zfp141's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenolic compound with diverse cellular effects. Potential indirect activator of Zfp141 through its antioxidant and epigenetic modulating properties. Resveratrol's role may involve influencing RNA polymerase II-mediated transcription by altering the chromatin landscape, promoting Zfp141 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural polyphenol affecting multiple signaling pathways. Potential indirect activator of Zfp141 through its anti-inflammatory and epigenetic modulation, influencing the transcriptional regulation by RNA polymerase II. Curcumin's role may involve suppressing inflammatory pathways and modifying chromatin accessibility, enhancing Zfp141 activity in the nucleus. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor impacting gene transcription. Potential indirect activator of Zfp141 by inhibiting bromodomain proteins, altering chromatin structure, and influencing RNA polymerase II activity. JQ1's role involves modulating the epigenetic landscape to facilitate Zfp141 binding to cis-regulatory regions and enhance its transcriptional regulatory function in the nucleus. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
HDAC inhibitor modulating gene expression. Potential indirect activator of Zfp141 by inhibiting HDACs, leading to increased histone acetylation and altered chromatin accessibility for RNA polymerase II. Sodium Butyrate's role involves epigenetic modifications that enhance Zfp141 binding to cis-regulatory regions, promoting transcriptional regulation in the nucleus. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Natural triterpenoid impacting multiple pathways. Potential indirect activator of Zfp141 through its anti-inflammatory and epigenetic modulating properties. Betulinic Acid's role involves influencing RNA polymerase II-mediated transcription by modifying chromatin accessibility, promoting Zfp141 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
PARP inhibitor impacting chromatin structure. Potential indirect activator of Zfp141 through PARP inhibition, influencing RNA polymerase II-mediated transcription. A-485's role involves modulating the chromatin environment to facilitate Zfp141 binding to cis-regulatory regions and enhance its transcriptional regulatory function in the nucleus. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor influencing DNA methylation. Potential indirect activator of Zfp141 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. Decitabine's role involves epigenetic modifications that enhance Zfp141's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||