5-Aza-2′-Deoxycytidine 5-Aza-2′-Deoxycytidine is a DNMT inhibitor shown to alter gene expression..

5-Aza-2′-Deoxycytidine (CAS 2353-33-5)

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別名: 5-Aza-2′-Deoxycytidine is also known as Decitabine.
アプリケーション: 5-Aza-2′-Deoxycytidine is a DNMT inhibitor shown to alter gene expression.
CAS 番号: 2353-33-5
Purity: ≥99%
Molecular Weight: 228.21
Molecular Formula: C8H12N4O4
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).

5-Aza-2′-Deoxycytidine is a Dnmt inhibitor shown to alter gene expression. 5-Aza-2′-Deoxycytidine has been reported to cause phosphorylation inhibition of 2′-deoxycytidine in certain cells and the incorporation of 2′-deoxycytidine into DNA. Experiments have shown that 5-Aza-2′-Deoxycytidine induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits methylation of newly synthesized DNA. DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention by 5-Aza-2′-Deoxycytidine can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2′-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, 5-Aza-2′-Deoxycytidine demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase. 5-Aza-2′-Deoxycytidine is also known as Decitabine, 5-Aza-CdR, 5-Aza-dC, and 2′-Deoxy-5-azacytidine.


参考文献

1. Veselý, J., et al., 1977. Incorporation of a potent antileukemic agent, 5-aza-2′-deoxycytidine, into DNA of cells from leukemic mice. Cancer research. 37(10): 3684-9. PMID: 71199

2. Jones, P A., et al., 1980. Cellular differentiation, cytidine analogs and DNA methylation. Cell. 20(1): 85-93. PMID: 6156004

3. Zhu, W G., et al., 2001. DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer research. 61(4): 1327-33. PMID: 11245429

4. Takebayashi, S., et al., 2001. 5-Aza-2′-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation. Biochemical and biophysical research communications. 288(4): 921-6. PMID: 11688997

用法 :
Long term storage: 2 years at -20°C (Powder); 6 monthsat -80°C (in DMSO).
Physical State :
Solid
Solubility :
Soluble in water (50 mM), methanol (1 mg/ml), DMSO (50 mg/ml), DMF (~20 mg/ml), and ethanol (5 mM).
保存方法 :
Store at 4° C
Melting Point :
~200° C (dec.)
Boiling Point :
485.80° C at 760 mmHg (Predicted)
Density :
1.91 g/cm3 (Predicted)
Refractive Index :
n20D 1.78 (Predicted)
Optical Activity :
α20D +72, c = 0.5 in water
IC50 :
Dnmt: IC50 = 4.38 nM (KG1a cells); Dnmt: IC50 = 438 nM (HL-60 cells)
pK Values :
pKb: 3.49 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
XZ3012000
PubChem CID :
Merck Index :
14: 2853
MDL Number :
MFCD00043011
EC Number :
219-089-4
Beilstein Registry :
617982
SMILES :
NC1=NC(=O)N(C=N1)[[email protected]]1C[[email protected]@H](O)[[email protected]@H](CO)O1

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5-Aza-2′-Deoxycytidine (CAS 2353-33-5)  参考文献

他の人が5-Aza-2′-Deoxycytidine (CAS 2353-33-5)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 3 of 3 合計

PMID: # 31215104  2019. Cancer Sci. 110: 2629-2642.

PMID: # 29457784  Jiang, G.|Nguyen, D.|Archin, NM.|Yukl, SA.|Méndez-Lagares, G.|Tang, Y.|Elsheikh, MM.|Thompson, GR.|Hartigan-O'Connor, DJ.|Margolis, DM.|Wong, JK.|Dandekar, S.| et al. 2018. J. Clin. Invest. 128: 1190-1198.

PMID: # 12591989  Sato, N. et al. 2003. J. Natl. Cancer Inst. 95: 327-330.

引用 1 to 3 of 3 合計
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