ZDHHC22 Activators
ZDHHC22, or Zinc Finger DHHC-Type Palmitoyltransferase 22, is a protein encoded by the ZDHHC22 gene in humans. Belonging to the DHHC (Asp-His-His-Cys) family of proteins, ZDHHC22 is categorized as a palmitoyltransferase, an enzyme that adds a palmitate (a type of fatty acid) to other proteins in a process known as palmitoylation.Palmitoylation is a reversible post-translational modification that increases the hydrophobicity of proteins, enhancing their association with cellular membranes. This modification can affect the protein's localization, stability, and interactions, thereby influencing its function and the overall cellular processes.
ZDHHC22, like other DHHC proteins, contains a conserved DHHC domain, which is essential for its enzymatic activity. This domain includes a cysteine-rich region that coordinates a zinc ion, necessary for the transfer of the palmitate group to target proteins.Dysregulation of palmitoylation processes can lead to various diseases, including neurological disorders and cancer, highlighting the importance of enzymes like ZDHHC22.In summary, ZDHHC22 is a palmitoyltransferase involved in the post-translational modification of proteins. It plays a role in regulating protein function by enhancing their association with cellular membranes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to transcriptional changes of multiple genes, potentially including ZDHHC22. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that may result in the demethylation of gene promoters, possibly upregulating the ZDHHC22 gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, this compound could promote a more open chromatin state, potentially enhancing ZDHHC22 gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression through retinoic acid receptors, potentially affecting the expression of ZDHHC22. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
By activating the NRF2 pathway, sulforaphane may induce the expression of detoxifying enzymes, and it could also influence ZDHHC22 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels, which may affect gene expression through the cAMP response element-binding protein (CREB), possibly affecting ZDHHC22. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid can regulate gene expression through glucocorticoid receptors, potentially altering ZDHHC22 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a primary female sex hormone, it can modulate gene expression through estrogen receptors, which could include ZDHHC22. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This green tea polyphenol may influence gene expression through epigenetic modifications and could potentially affect ZDHHC22. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate sirtuins and other pathways related to cellular stress and aging, potentially influencing ZDHHC22 expression. | ||||||