ZDHHC22 Antibody (C-5): sc-514005

ZDHHC22 Antibody (C-5) is a mouse monoclonal IgM antibody that detects ZDHHC22 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZDHHC22 antibody (C-5) is available as the non-conjugated form. ZDHHC22, also known as zinc finger, DHHC domain containing 22, is a 263 amino acid multi-pass membrane protein that plays a crucial role as a palmitoyltransferase, facilitating the addition of palmitate to cysteine residues on target proteins. This post-translational modification is vital for regulating protein localization, stability, and interactions, thereby influencing various cellular processes, including signal transduction and membrane trafficking. The gene encoding ZDHHC22 is located on human chromosome 14, a region that harbors over 700 genes and is implicated in several genetic disorders and diseases, including Alzheimer′s disease and α1-antitrypsin deficiency. The ability of ZDHHC22 to modify proteins through palmitoylation highlights its potential as a biomarker for early detection of colon neoplasia, making ZDHHC22 (C-5) monoclonal antibody an essential tool for researchers studying these critical pathways in human health and disease.

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ZDHHC22 Antibody (C-5) References:

1. The DHHC domain: a new highly conserved cysteine-rich motif.  |  Putilina, T., et al. 1999. Mol Cell Biochem. 195: 219-26. PMID: 10395086
2. The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase.  |  Roth, AF., et al. 2002. J Cell Biol. 159: 23-8. PMID: 12370247
3. The DNA sequence and analysis of human chromosome 14.  |  Heilig, R., et al. 2003. Nature. 421: 601-7. PMID: 12508121
4. Protein palmitoylation by a family of DHHC protein S-acyltransferases.  |  Mitchell, DA., et al. 2006. J Lipid Res. 47: 1118-27. PMID: 16582420
5. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.  |  Ohno, Y., et al. 2006. Biochim Biophys Acta. 1761: 474-83. PMID: 16647879
6. Gain of 5p15.33 is associated with progression of bladder cancer.  |  Yamamoto, Y., et al. 2007. Oncology. 72: 132-8. PMID: 18025801

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZDHHC22 Antibody (C-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ZDHHC22 Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZDHHC22 Antibody (C-5) Specifications

Alternate Product Name: ZDHHC22

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 68-90

Epitope Target: ZDHHC22

Epitope Species: human

Product Reactivity/Detection: ZDHHC22

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ZDHHC22 Antibody (C-5): P: Blocking Peptide