ZDHHC18 Activators constitute a specialized category of chemical compounds that have garnered interest in the field of molecular biology and cellular research. These activators are designed to modulate the activity of the ZDHHC18 gene, where ZDHHC18 stands for Zinc Finger, DHHC-Type Containing 18. This gene is a protein-coding element found in humans, and it belongs to a family of enzymes known as palmitoyltransferases. Palmitoyltransferases play a pivotal role in post-translational modification by catalyzing the addition of fatty acid groups, primarily palmitate, to specific protein targets. This modification, called palmitoylation, is essential for regulating protein localization, stability, and function within cells. ZDHHC18 Activators represent a group of molecules engineered to enhance or stimulate the expression and function of the ZDHHC18 gene, ultimately leading to an increase in the activity of the associated palmitoyltransferase enzyme.
The mechanism of action of ZDHHC18 Activators generally involves their interaction with specific regulatory elements within the ZDHHC18 gene, such as promoter regions or enhancer sequences. These interactions facilitate the upregulation of gene transcription, resulting in heightened synthesis of the ZDHHC18 enzyme. ZDHHC18 is believed to play a role in the palmitoylation of various protein targets, which can impact cellular processes, including membrane trafficking, protein-protein interactions, and signal transduction. As scientists delve deeper into the functions and potential implications of ZDHHC18 activation, the development and refinement of ZDHHC18 Activators offer the prospect of advancing our understanding of post-translational modifications, cellular biology, and the broader role of ZDHHC18 in cellular functionality and molecular pathways, potentially revealing novel aspects of protein regulation and cellular responses.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may modulate transcriptional regulation by influencing signal transduction pathways that could lead to the induction of ZDHHC18 expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases, potentially elevating cAMP levels and influencing gene transcription, possibly including ZDHHC18. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Sodium valproate, as a histone deacetylase inhibitor, may facilitate chromatin remodeling, possibly impacting ZDHHC18 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation and could elicit ER stress, indirectly influencing gene expression, including ZDHHC18. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $88.00 $118.00 | 10 | |
2-Mercaptoethanol can modify the redox state of cells, potentially affecting transcription factors and possibly ZDHHC18 expression. | ||||||
Sodium arsenite, 0.1N Standardized Solution | 7784-46-5 | sc-301816 | 500 ml | $130.00 | 4 | |
Sodium arsenite can induce oxidative stress which may affect transcription factor activity and could influence ZDHHC18 expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine interferes with lysosomal activity and autophagy, which could have secondary effects on gene regulation, including ZDHHC18. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 acts through the vitamin D receptor to regulate gene transcription, potentially affecting the expression of ZDHHC18. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, activates PKA signaling and could potentially enhance ZDHHC18 gene transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and can inhibit transcription globally, potentially impacting ZDHHC18 expression when administered at low doses. |