ZCWPW1 Inhibitors
ZCWPW1 inhibitors encompass a range of chemical compounds that primarily modulate epigenetic markers, such as histone acetylation and DNA methylation, to indirectly decrease the functional activity of ZCWPW1. Compounds like Trichostatin A, Entinostat, Vorinostat, Mocetinostat, Panobinostat, Romidepsin, Valproic Acid, Belinostat, and Chidamide operate as histone deacetylase inhibitors. These inhibitors lead to an accumulation of acetylated histones, resulting in a more open chromatin structure which can influence the transcriptional activity of various genes, including ZCWPW1. By altering the chromatin state around the ZCWPW1 gene locus, these compounds can decrease its expression and subsequently its activity within the cell, given that ZCWPW1 is implicated in processes involving gene regulation through recognition of histone methylation marks.
Additionally, agents such as 5-Azacytidine, RG108, and Decitabine work by inhibiting DNA methyltransferases, thereby reducing DNA methylation levels. This hypomethylation can lead to transcriptional changes that may include the downregulation of ZCWPW1 expression. Since DNA methylation is a mechanism for the silencing of gene expression, the action of these inhibitors could result in decreased levels of ZCWPW1 mRNA and protein, indirectly inhibiting its activity. Overall, the concerted action of these epigenetic modifiers provides a multifaceted approach to controlling ZCWPW1 activity, targeting the epigenetic landscape that regulates its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can prevent the deacetylation of histones, leading to a more open chromatin structure and potentially affecting the expression of ZCWPW1 by altering its transcriptional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into DNA and RNA and acts as a DNA methyltransferase inhibitor, reducing DNA methylation. Hypomethylation of the ZCWPW1 gene could potentially decrease its expression as DNA methylation can be a mechanism for the gene silencing. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a non-nucleoside DNA methyltransferase inhibitor, preventing DNA methylation. This could lead to transcriptional changes in genes like ZCWPW1, possibly decreasing its expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat is a selective histone deacetylase inhibitor that can alter gene expression by affecting chromatin structure. This can indirectly lead to decreased expression of ZCWPW1 by altering the acetylation status of histones associated with its gene. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, can change the expression of numerous genes, potentially including ZCWPW1 by promoting a relaxed chromatin state that could decrease its gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a cytidine analog used as a DNA methyltransferase inhibitor, leading to reduced methylation and potentially decreased expression of specific genes like ZCWPW1. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that can modify the transcription of genes by affecting chromatin accessibility, potentially leading to a decrease in ZCWPW1 expression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent histone deacetylase inhibitor that can broadly influence gene expression, potentially leading to downregulation of ZCWPW1 through alterations in the chromatin landscape. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a histone deacetylase inhibitor that impacts gene expression by altering chromatin structure, which could lead to transcriptional repression of ZCWPW1. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, can affect gene expression by changing the histone acetylation status, potentially reducing ZCWPW1 expression. | ||||||